Bower C, Stanley F J
Western Australian Birth Defects Registry, King Edward Memorial Hospital, Subiaco.
Am J Med Genet. 1992 Nov 15;44(5):647-50. doi: 10.1002/ajmg.1320440524.
In a population-based case-control study of dietary folate and neural tube defects, information was collected by interview and self-administered questionnaires from the mothers of cases with only neural tube defects, from the mothers of matched control infants with defects other than neural tube defects, and from the mothers of matched live-born infants with no birth defects. The association of midline birth defects (excluding neural tube defects) with dietary folate intake in the first 6 weeks of pregnancy was assessed by restricting the analysis to the 59 mothers of infants with midline defects in the first control group and comparing them with their matched control infants in the second control group. The crude and adjusted odds ratios for dietary folate and for folic acid supplementation were close to one, and all confidence intervals embraced unity. These data do not provide evidence of an association between midline birth defects (excluding neural tube defects) and either dietary folate or folic acid supplementation.
在一项基于人群的膳食叶酸与神经管缺陷病例对照研究中，通过访谈和自填问卷收集了仅患有神经管缺陷病例的母亲、匹配的非神经管缺陷缺陷对照婴儿的母亲以及匹配的无出生缺陷活产婴儿的母亲的信息。通过将分析限制在第一对照组中59名患有中线缺陷婴儿的母亲，并将她们与第二对照组中匹配的对照婴儿进行比较，评估了妊娠前6周中线出生缺陷（不包括神经管缺陷）与膳食叶酸摄入量之间的关联。膳食叶酸和叶酸补充剂的粗比值比和调整后比值比接近1，所有置信区间都包含1。这些数据没有提供中线出生缺陷（不包括神经管缺陷）与膳食叶酸或叶酸补充剂之间存在关联的证据。
