Marangoni R, Savino R, Colombo R, Cimino R, Civardi F
Nephrology and Dialysis Unit, Bollate Hospital, Milan, Italy.
Artif Organs. 1992 Dec;16(6):547-52. doi: 10.1111/j.1525-1594.1992.tb00550.x.
With the aim of treating with short sessions even chronic uremic patients with cardiovascular instability, we have developed our previous findings about paired filtration dialysis (hemofiltration-hemodialysis in series) by a method we call high-efficiency paired filtration dialysis (HEPFD). We have treated with this method for 6 months 6 chronic anuric uremic patients previously treated for 6 months with hemofiltration (HF) because of their cardiovascular instability. By comparison with HF, HEPFD shows much higher clearances of small molecules with consequent significant decrease of their predialytic values, improvement of Kt/V value, lower beta 2-microglobulin clearance (its predialytic value remains unchanged), and the same tolerability. HEPFD allows short, efficient, and well-tolerated treatments even in patients with cardiovascular instability.
为了即使是患有心血管不稳定的慢性尿毒症患者也能用短疗程进行治疗，我们通过一种我们称为高效配对过滤透析（HEPFD）的方法，拓展了我们之前关于配对过滤透析（串联血液滤过-血液透析）的研究结果。我们用这种方法对6例慢性无尿尿毒症患者进行了6个月的治疗，这些患者此前因心血管不稳定接受了6个月的血液滤过（HF）治疗。与HF相比，HEPFD显示出小分子清除率更高，其透析前值显著降低，Kt/V值得到改善，β2-微球蛋白清除率更低（其透析前值保持不变），并且耐受性相同。HEPFD即使在心血管不稳定的患者中也能进行短时间、高效且耐受性良好的治疗。
