多巴胺拮抗剂在自发性和迟发性运动障碍中的作用。

The effect of dopamine antagonists in spontaneous and tardive dyskinesia.

作者信息

Fog R

出版信息

Psychopharmacology Suppl. 1985;2:118-21. doi: 10.1007/978-3-642-70140-5_15.

Abstract

Dopamine antagonists are effective in suppressing hyperkinetic symptoms in patients with tardive dyskinesia, spontaneous oral dyskinesia, Huntington's chorea, and Gilles de la Tourette's syndrome. These neuroleptics have no curative effect upon the conditions and may even aggravate symptoms in the long term. In many cases a single neuroleptic drug may lose its effect. A more lasting effect may be obtained by combining drugs with pre- and postsynaptic antidopamine effects.

摘要

多巴胺拮抗剂可有效抑制迟发性运动障碍、自发性口腔运动障碍、亨廷顿舞蹈症和抽动秽语综合征患者的运动亢进症状。这些抗精神病药物对这些病症并无治愈作用，从长期来看甚至可能会加重症状。在许多情况下，单一抗精神病药物可能会失效。通过将具有突触前和突触后抗多巴胺作用的药物联合使用，或许能获得更持久的疗效。