人嗜T淋巴细胞病毒1型（HTLV-1）在HTLV-1携带大鼠中的垂直传播
Vertical transmission of HTLV-1 in HTLV-1 carrier rat.
作者信息
Ami Y, Kushida S, Matsumura M, Yoshida Y, Kameyama T, Sugiyama Y, Yagami K, Uchida M, Uchida K, Koiso K
机构信息
Institute of Basic Medical Sciences, University of Tsukuba, Ibaraki.
出版信息
Jpn J Cancer Res. 1992 Dec;83(12):1241-3. doi: 10.1111/j.1349-7006.1992.tb02751.x.
Abstract
A female F344 rat was injected with 2.4 x 10(6) MT-2 cells intravenously at 3 and 4 weeks old, and was mated with a non-infected male rat at the 17th week after injection, when the dam rat contained HTLV-1 provirus in the peripheral blood mononuclear cells as determined by polymerase chain reaction. HTLV-1 provirus was detected in at least 2 out of 9 offspring. This system should be useful for studies on the routes and prevention of vertical transmission and on elimination of once-transmitted HTLV-1.
摘要
一只雌性F344大鼠在3周龄和4周龄时经静脉注射了2.4×10⁶个MT - 2细胞，并在注射后第17周与一只未感染的雄性大鼠交配，此时通过聚合酶链反应测定发现母鼠外周血单核细胞中含有HTLV - 1前病毒。在9只后代中至少有2只检测到HTLV - 1前病毒。该系统对于研究垂直传播的途径和预防以及消除一旦传播的HTLV - 1应该是有用的。
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本文引用的文献
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