Davies F W, White M, Kenny G N
University Department of Anaesthesia, Royal Infirmary, Glasgow, UK.
Int J Clin Monit Comput. 1992 Dec;9(4):207-12. doi: 10.1007/BF01133615.
A Psion microcomputer controlled infusion system for alfentanil was assessed for the provision of post-operative analgesia in 14 patients who had undergone aortic bifurcation graft surgery. The system employed a pharmacokinetic model working in real time to deliver any selected target plasma concentration of alfentanil. The alfentanil infusion system was used for a mean time of 39 hours and for 96% of this time, patients were scored as having no pain or only mild pain. Severe pain was recorded for only 0.05% of the study time. The use of a pharmacokinetic delivery system may offer a convenient and simple method of providing postoperative analgesia with alfentanil.
对一种用于阿芬太尼的Psion微型计算机控制输注系统进行了评估，该系统用于为14例接受主动脉分叉移植手术的患者提供术后镇痛。该系统采用实时运行的药代动力学模型，以输送任何选定的阿芬太尼目标血浆浓度。阿芬太尼输注系统的平均使用时间为39小时，在此期间的96%，患者被评定为无疼痛或仅有轻度疼痛。在研究时间中，仅0.05%记录有重度疼痛。使用药代动力学给药系统可能为使用阿芬太尼提供术后镇痛提供一种方便、简单的方法。
