Owen H, Brose W G, Plummer J L, Mather L E
Department of Anaesthesia and Intensive Care, Flinders Medical Centre, Bedford Park, Adelaide, South Australia.
Anaesthesia. 1990 Jun;45(6):452-5. doi: 10.1111/j.1365-2044.1990.tb14332.x.
Patient-controlled infusion-demand analgesia was studied using alfentanil. We were unable to identify an optimal dose and administration rate; doses required range from 100 to 900 micrograms alfentanil. The mean concentration of alfentanil in blood associated with return of pain (i.e. immediately before demand) was 58 ng/ml on day 1 and 37 ng/ml on day 2. This difference was despite similar drug consumption on both days.
使用阿芬太尼对患者自控按需镇痛进行了研究。我们未能确定最佳剂量和给药速率；所需剂量范围为100至900微克阿芬太尼。与疼痛复发（即紧接按需给药前）相关的血液中阿芬太尼平均浓度在第1天为58纳克/毫升，在第2天为37纳克/毫升。尽管两天的药物消耗量相似，但仍存在这种差异。
