Valentine B A, George C, Randolph J F, Center S A, Fuhrer L, Beck K A
Department of Pathology, New York State College of Veterinary Medicine, Cornell University, Ithaca 14853-6401.
J Vet Intern Med. 1992 Nov-Dec;6(6):335-40. doi: 10.1111/j.1939-1676.1992.tb00366.x.
Clinical, radiographic, electromyographic, and pathologic findings in a cat with fibrodysplasia ossificans progressiva are described. The features of five previously reported cases of this feline disorder are also presented. This disorder affects young adult to middle-aged cats of both sexes. Characteristic clinical features include progressive stiffness of gait, with enlargement of proximal limb musculature. Radiography reveals multiple mineralized densities within the affected musculature. The clinical course is rapid, with development of severe disability within 2 weeks to several months. Electromyographic and pathologic findings suggest that this is a disorder of connective tissue, affecting primarily the epimysium, tendons, and fasciae, and results in marked proliferation of fibrovascular connective tissue, with associated chondroid and osseous metaplasia.
描述了一只患有进行性骨化性纤维发育不良的猫的临床、影像学、肌电图和病理检查结果。还介绍了此前报道的5例这种猫科疾病的特征。这种疾病影响成年早期到中年的雌雄猫。特征性临床特征包括步态逐渐僵硬，近端肢体肌肉组织肿大。放射学检查显示受累肌肉组织内有多个矿化密度影。临床病程进展迅速，在2周内至数月内发展为严重残疾。肌电图和病理检查结果表明，这是一种结缔组织疾病，主要影响肌外膜、肌腱和筋膜，并导致纤维血管结缔组织显著增生，伴有软骨样化生和骨化生。
