Stephan F K
Department of Psychology, Florida State University, Tallahassee 32306-1051.
Physiol Behav. 1992 Nov;52(5):997-1008. doi: 10.1016/0031-9384(92)90382-c.
Rats with lesions of the suprachiasmatic nuclei were exposed to daily feeding until anticipatory activity (AA) developed. Meals were then phase advanced or delayed and presented for 1-4 consecutive days. The phase of the circadian pacemaker was assessed during probes of total food deprivation before or after 8 days of intervening ad lib feeding. One or two food pulses caused phase delays for one cycle but were insufficient to reset the feeding entrainable pacemaker. Complete or partial resetting to 6- or 9-h advances or delays was observed in some rats after three food pulses and in all rats after four food pulses. In some rats, phase shifts of meals appeared to induce both advancing and delaying transients, and two bouts of AA appeared during food-deprivation probes. This suggests that the feeding entrainable pacemaker consists of two or more oscillators which became uncoupled after phase shifts. The persistence of AA at the preshift phase observed after initial phase delays, concomitantly with AA to the phase shifted meals, also suggests the presence of a second oscillator.
对视交叉上核受损的大鼠进行每日喂食，直至出现预期活动（AA）。然后将进餐时间提前或推迟，并连续呈现1 - 4天。在自由进食8天前后的完全食物剥夺探测期间，评估昼夜节律起搏器的相位。一两个食物脉冲会导致一个周期的相位延迟，但不足以重置可被进食夹带的起搏器。在一些大鼠中，三个食物脉冲后观察到完全或部分重置为提前6或9小时或延迟，四个食物脉冲后在所有大鼠中均观察到。在一些大鼠中，进餐的相位变化似乎会诱导提前和延迟的瞬变，并且在食物剥夺探测期间出现两波预期活动。这表明可被进食夹带的起搏器由两个或更多振荡器组成，这些振荡器在相位变化后会解耦。在最初的相位延迟后，在预移位阶段观察到预期活动的持续存在，同时伴随着对相位变化后的进餐出现预期活动，这也表明存在第二个振荡器。
