T淋巴细胞对H-2突变体的反应。I. 增殖依赖于Ly 1+2+细胞。
T-lymphocyte response to H-2 mutants. I. Proliferation is dependent on Ly 1+2+ cells.
作者信息
Wettstein P J, Bailey D W, Mobraaten L E, Klein J, Frelinger J A
出版信息
J Exp Med. 1978 May 1;147(5):1395-1404. doi: 10.1084/jem.147.5.1395.
Abstract
We have determined the Ly phenotype of the T lymphocytes which proliferate in response to mutant H-2K and H-2D alloantigens in primary mixed lymphocyte culture. Responder T cells proliferating in reciprocal cultures of H-2d(KdDd) and H-2da(KdDda) lymphocytes were typed Ly 2+ through selective depletion with specific alloantiserum plus complement. Further, B6-Ly 1a lymphocytes proliferating in response to B6-H-2ba and B6-H-2bf stimulators were typed as Ly 1+2+ through similar analysis. These results are discussed with regard to their impact on views of lymphocyte differentiation and factors determining the identity of alloreactive lymphocytes.
摘要
我们已经确定了在原发性混合淋巴细胞培养中对突变型H-2K和H-2D同种异体抗原产生增殖反应的T淋巴细胞的Ly表型。在H-2d（KdDd）和H-2da（KdDda）淋巴细胞的相互培养中增殖的应答T细胞，通过用特异性同种异体抗血清加补体进行选择性耗竭，被分型为Ly 2+。此外，通过类似分析，对B6-H-2ba和B6-H-2bf刺激物产生增殖反应的B6-Ly 1a淋巴细胞被分型为Ly 1+2+。讨论了这些结果对淋巴细胞分化观点以及决定同种反应性淋巴细胞身份的因素的影响。
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