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1
T-lymphocyte response to H-2 mutants. I. Proliferation is dependent on Ly 1+2+ cells.T淋巴细胞对H-2突变体的反应。I. 增殖依赖于Ly 1+2+细胞。
J Exp Med. 1978 May 1;147(5):1395-1404. doi: 10.1084/jem.147.5.1395.
2
T lymphocyte response to H-2 mutants: cytotoxic effectors are Ly-1+2+.T淋巴细胞对H-2突变体的反应：细胞毒性效应细胞为Ly-1+2+。
Proc Natl Acad Sci U S A. 1979 Jul;76(7):3455-9. doi: 10.1073/pnas.76.7.3455.
3
T lymphocyte responses to non-H-2 histocompatibility antigens. I. Role of Ly-1+2+ T cells as cytotoxic effectors and requirement for Ly-1+2+ T cells for optimal generation of cytotoxic effectors.T淋巴细胞对非H-2组织相容性抗原的反应。I. Ly-1+2+ T细胞作为细胞毒性效应细胞的作用以及产生最佳细胞毒性效应细胞对Ly-1+2+ T细胞的需求。
J Immunol. 1981 Jul;127(1):43-6.
4
The use of a clonal assay for cytotoxic T lymphocytes to determine the Ly phenotypes of the cytotoxic precursor and effector cells to alloantigens and trinitrophenyl-modified self antigens.使用细胞毒性T淋巴细胞的克隆分析来确定细胞毒性前体细胞和效应细胞针对同种异体抗原和三硝基苯基修饰的自身抗原的Ly表型。
J Immunol. 1980 Nov;125(5):1977-86.
5
Differential allo-response of murine thymocytes to H- 2 K region different recombinants and to H-2Kb mutants.小鼠胸腺细胞对H-2 K区域不同重组体和H-2Kb突变体的差异同种异体反应。
J Immunol. 1980 May;124(5):2464-7.
6
L3T4+ cytotoxic T lymphocytes specific for class I H-2 antigens are activated in primary mixed lymphocyte reactions.对I类H-2抗原具有特异性的L3T4+细胞毒性T淋巴细胞在初次混合淋巴细胞反应中被激活。
J Immunol. 1987 Dec 15;139(12):4007-15.
7
Cooperation between subclass of T lymphocytes in the in vitro generation of cytotoxicity against a mutant H-2K difference. An analysis with anti-Lyt antisera.T淋巴细胞亚类在体外产生针对突变型H-2K差异的细胞毒性中的合作。用抗Lyt抗血清进行的分析。
Eur J Immunol. 1979 Jan;9(1):7-12. doi: 10.1002/eji.1830090103.
8
Expression of Qat-4 and Qat-5 alloantigens on cytotoxic precursor and effector cells: different surface phenotypes of alloreactive and H-2 restricted cytotoxic T cells.Qat-4和Qat-5同种异体抗原在细胞毒性前体细胞和效应细胞上的表达：同种反应性和H-2限制性细胞毒性T细胞的不同表面表型。
Eur J Immunol. 1982 Jan;12(1):43-50. doi: 10.1002/eji.1830120110.
9
Studies of murine lymphocyte alloantigens Ly-7.2.小鼠淋巴细胞同种抗原Ly-7.2的研究
Exp Clin Immunogenet. 1984;1(3):158-69.
10
Antigen and MHC restriction specificity of two types of cloned male-specific T cell lines.两种克隆化的雄性特异性T细胞系的抗原及主要组织相容性复合体限制特异性
J Immunol. 1983 Oct;131(4):1641-5.

引用本文的文献

1
Significance of Lyt phenotypes: Lyt2 antibodies block activities of T cells that recognize class 1 major histocompatibility complex antigens regardless of their function.Lyt表型的意义：Lyt2抗体可阻断识别1类主要组织相容性复合体抗原的T细胞的活性，无论其功能如何。
Proc Natl Acad Sci U S A. 1981 Nov;78(11):7101-5. doi: 10.1073/pnas.78.11.7101.
2
Interaction between MHC-encoded products and cloned T cells. II. Analyses of physiological requirements indicate two different pathways of stimulation by class I alloantigens.MHC编码产物与克隆化T细胞之间的相互作用。II. 生理需求分析表明I类同种异体抗原存在两种不同的刺激途径。
Immunogenetics. 1984;19(4):279-94. doi: 10.1007/BF00345401.
3
Alloreactive T-cell clones. Ly phenotypes predict both function and specificity for major histocompatibility complex products.同种反应性T细胞克隆。Ly表型可预测对主要组织相容性复合体产物的功能和特异性。
Immunogenetics. 1983;17(2):147-65. doi: 10.1007/BF00364755.
4
Enhancement of T lymphocyte functions by Fc fragments of immunoglobulins. I. Augmentation of allogeneic mixed lymphocyte culture reactions requires I-A- or I-B-subregion differences between effector and stimulator cell populations.免疫球蛋白Fc片段对T淋巴细胞功能的增强作用。I. 同种异体混合淋巴细胞培养反应的增强需要效应细胞和刺激细胞群体之间存在I-A或I-B亚区差异。
J Exp Med. 1981 May 1;153(5):1161-72. doi: 10.1084/jem.153.5.1161.
5
T cells discriminate between Ia antigens expressed on allogeneic accessory cells and B cells: a potential function for carbohydrate side chains on Ia molecules.T细胞能够区分同种异体辅助细胞和B细胞上表达的Ia抗原：Ia分子上碳水化合物侧链的潜在功能。
Proc Natl Acad Sci U S A. 1983 Oct;80(19):6000-4. doi: 10.1073/pnas.80.19.6000.
6
Interactions between MHC-encoded products and cloned T-cells. I. Fine specificity of induction of proliferation and lysis.主要组织相容性复合体（MHC）编码产物与克隆化T细胞之间的相互作用。I. 增殖与裂解诱导的精细特异性
Immunogenetics. 1982;16(6):533-49. doi: 10.1007/BF00372022.
7
T cell subsets participating in the generation of cytotoxic T cells.参与细胞毒性T细胞生成的T细胞亚群。
Springer Semin Immunopathol. 1980 May;3(1):39-62. doi: 10.1007/BF00199925.
8
Characterization of two distinct primary T cell populations that secrete interleukin 2 upon recognition of class I or class II major histocompatibility antigens.两种不同的初始T细胞群体的特征，这两种群体在识别I类或II类主要组织相容性抗原后会分泌白细胞介素2 。
J Exp Med. 1986 Mar 1;163(3):603-19. doi: 10.1084/jem.163.3.603.
9
T-T-cell interactions during the vitro cytotoxic allograft responses. I. Soluble products from activated Lyl+ T cells trigger autonomously antigen-primed Ly23+ T cells to cell proliferation and cytolytic activity.体外细胞毒性同种异体移植反应中的T - T细胞相互作用。I. 活化的Lyl + T细胞产生的可溶性产物可自主触发经抗原致敏的Ly23 + T细胞进行细胞增殖和细胞溶解活性。
J Exp Med. 1978 Dec 1;148(6):1523-38. doi: 10.1084/jem.148.6.1523.
10
T lymphocyte response to H-2 mutants: cytotoxic effectors are Ly-1+2+.T淋巴细胞对H-2突变体的反应：细胞毒性效应细胞为Ly-1+2+。
Proc Natl Acad Sci U S A. 1979 Jul;76(7):3455-9. doi: 10.1073/pnas.76.7.3455.

本文引用的文献

1
Inherited histocompatibility changes in progeny of irradiated and unirradiated inbred mice.受辐照和未受辐照近交系小鼠后代的遗传性组织相容性变化
Genet Res. 1965 Nov;6(3):330-40. doi: 10.1017/s0016672300004225.
2
Ly-C: a third locus specifying alloantigens expressed only on thymocytes and lymphocytes.Ly-C：第三个基因座，它决定了仅在胸腺细胞和淋巴细胞上表达的同种异体抗原。
Transplantation. 1971 Mar;11(3):351-3.
3
A rapid method for the isolation of functional thymus-derived murine lymphocytes.一种分离功能性胸腺来源的小鼠淋巴细胞的快速方法。
Eur J Immunol. 1973 Oct;3(10):645-9. doi: 10.1002/eji.1830031011.
4
Histoincompatibilities found between congenic strains which differ at loci determing differentiation antigens.
Transplantation. 1973 Nov;16(5):505-14. doi: 10.1097/00007890-197311000-00016.
5
Immune responses in vitro. I. Culture conditions for antibody synthesis.体外免疫反应。I. 抗体合成的培养条件。
Cell Immunol. 1972 Feb;3(2):264-76. doi: 10.1016/0008-8749(72)90165-7.
6
New lymphocyte antigen system (Lna) controlled by the Ir region of the mouse H-2 complex.由小鼠H-2复合体的Ir区域控制的新淋巴细胞抗原系统（Lna）。
Proc Natl Acad Sci U S A. 1973 Sep;70(9):2509-14. doi: 10.1073/pnas.70.9.2509.
7
Ly-4, a new locus determining a lymphocyte cell-surface alloantigen in mice.Ly-4，一个决定小鼠淋巴细胞细胞表面同种异体抗原的新基因座。
Proc Natl Acad Sci U S A. 1973 Apr;70(4):1108-11. doi: 10.1073/pnas.70.4.1108.
8
Serologically defined and lymphocyte-defined components of the major histocompatibility complex in the mouse.小鼠主要组织相容性复合体的血清学定义成分和淋巴细胞定义成分。
J Exp Med. 1972 Dec 1;136(6):1430-44. doi: 10.1084/jem.136.6.1430.
9
Ly-A and Ly-B: two systems of lymphocyte isoantigens in the mouse.Ly - A和Ly - B：小鼠淋巴细胞同种抗原的两个系统。
Proc R Soc Lond B Biol Sci. 1968 Jun 11;170(1019):175-93. doi: 10.1098/rspb.1968.0032.
10
A miniaturized mouse mixed leukocyte culture in serum-free and mouse serum supplemented media.一种在无血清和添加小鼠血清的培养基中的小型化小鼠混合白细胞培养。
J Immunol Methods. 1973 Oct;3(2):147-63. doi: 10.1016/0022-1759(73)90030-6.

T淋巴细胞对H-2突变体的反应。I. 增殖依赖于Ly 1+2+细胞。

T-lymphocyte response to H-2 mutants. I. Proliferation is dependent on Ly 1+2+ cells.

作者信息

Wettstein P J, Bailey D W, Mobraaten L E, Klein J, Frelinger J A

出版信息

J Exp Med. 1978 May 1;147(5):1395-1404. doi: 10.1084/jem.147.5.1395.

DOI:10.1084/jem.147.5.1395
PMID:148487
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC2184279/
Abstract

We have determined the Ly phenotype of the T lymphocytes which proliferate in response to mutant H-2K and H-2D alloantigens in primary mixed lymphocyte culture. Responder T cells proliferating in reciprocal cultures of H-2d(KdDd) and H-2da(KdDda) lymphocytes were typed Ly 2+ through selective depletion with specific alloantiserum plus complement. Further, B6-Ly 1a lymphocytes proliferating in response to B6-H-2ba and B6-H-2bf stimulators were typed as Ly 1+2+ through similar analysis. These results are discussed with regard to their impact on views of lymphocyte differentiation and factors determining the identity of alloreactive lymphocytes.

摘要

我们已经确定了在原发性混合淋巴细胞培养中对突变型H-2K和H-2D同种异体抗原产生增殖反应的T淋巴细胞的Ly表型。在H-2d（KdDd）和H-2da（KdDda）淋巴细胞的相互培养中增殖的应答T细胞，通过用特异性同种异体抗血清加补体进行选择性耗竭，被分型为Ly 2+。此外，通过类似分析，对B6-H-2ba和B6-H-2bf刺激物产生增殖反应的B6-Ly 1a淋巴细胞被分型为Ly 1+2+。讨论了这些结果对淋巴细胞分化观点以及决定同种反应性淋巴细胞身份的因素的影响。