免疫球蛋白Fc片段对T淋巴细胞功能的增强作用。I. 同种异体混合淋巴细胞培养反应的增强需要效应细胞和刺激细胞群体之间存在I-A或I-B亚区差异。
Enhancement of T lymphocyte functions by Fc fragments of immunoglobulins. I. Augmentation of allogeneic mixed lymphocyte culture reactions requires I-A- or I-B-subregion differences between effector and stimulator cell populations.
作者信息
Morgan E L, Thoman M L, Weigle W O
出版信息
J Exp Med. 1981 May 1;153(5):1161-72. doi: 10.1084/jem.153.5.1161.
Abstract
Fc fragments derived from human Ig were found to be capable of enhancing T cell-mediated, antigen-induced proliferative and mixed lymphocyte culture responses. Maximum enhancement occurred when suboptimal amounts of antigen or suboptimal numbers of stimulator cells were employed. Augmentation of the allogeneic mixed lymphocyte culture reaction requires an I-A and/or I-B subregion difference between effector and stimulator cell populations. Although a significant proliferative response was observed with K- or D- region differences, Fc fragments were unable to enhance the response. The T cell population acted upon by Fc fragments in the potentiation of these responses bears the Lyt-1(+)23(-) phenotype.
摘要
人们发现，源自人免疫球蛋白的Fc片段能够增强T细胞介导的、抗原诱导的增殖反应以及混合淋巴细胞培养反应。当使用次优剂量的抗原或次优数量的刺激细胞时，增强效果最为显著。同种异体混合淋巴细胞培养反应的增强需要效应细胞和刺激细胞群体之间存在I-A和/或I-B亚区差异。尽管观察到K区或D区差异会引发显著的增殖反应，但Fc片段无法增强这种反应。在这些反应的增强过程中，受Fc片段作用的T细胞群体具有Lyt-1(+)23(-)表型。
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