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免疫球蛋白Fc片段对T淋巴细胞功能的增强作用。I. 同种异体混合淋巴细胞培养反应的增强需要效应细胞和刺激细胞群体之间存在I-A或I-B亚区差异。

Enhancement of T lymphocyte functions by Fc fragments of immunoglobulins. I. Augmentation of allogeneic mixed lymphocyte culture reactions requires I-A- or I-B-subregion differences between effector and stimulator cell populations.

作者信息

Morgan E L, Thoman M L, Weigle W O

出版信息

J Exp Med. 1981 May 1;153(5):1161-72. doi: 10.1084/jem.153.5.1161.

DOI:10.1084/jem.153.5.1161
PMID:6454744
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC2186150/
Abstract

Fc fragments derived from human Ig were found to be capable of enhancing T cell-mediated, antigen-induced proliferative and mixed lymphocyte culture responses. Maximum enhancement occurred when suboptimal amounts of antigen or suboptimal numbers of stimulator cells were employed. Augmentation of the allogeneic mixed lymphocyte culture reaction requires an I-A and/or I-B subregion difference between effector and stimulator cell populations. Although a significant proliferative response was observed with K- or D- region differences, Fc fragments were unable to enhance the response. The T cell population acted upon by Fc fragments in the potentiation of these responses bears the Lyt-1(+)23(-) phenotype.

摘要

人们发现，源自人免疫球蛋白的Fc片段能够增强T细胞介导的、抗原诱导的增殖反应以及混合淋巴细胞培养反应。当使用次优剂量的抗原或次优数量的刺激细胞时，增强效果最为显著。同种异体混合淋巴细胞培养反应的增强需要效应细胞和刺激细胞群体之间存在I-A和/或I-B亚区差异。尽管观察到K区或D区差异会引发显著的增殖反应，但Fc片段无法增强这种反应。在这些反应的增强过程中，受Fc片段作用的T细胞群体具有Lyt-1(+)23(-)表型。

相似文献

1
Enhancement of T lymphocyte functions by Fc fragments of immunoglobulins. I. Augmentation of allogeneic mixed lymphocyte culture reactions requires I-A- or I-B-subregion differences between effector and stimulator cell populations.免疫球蛋白Fc片段对T淋巴细胞功能的增强作用。I. 同种异体混合淋巴细胞培养反应的增强需要效应细胞和刺激细胞群体之间存在I-A或I-B亚区差异。
J Exp Med. 1981 May 1;153(5):1161-72. doi: 10.1084/jem.153.5.1161.
2
Enhancement of T. lymphocyte functions by Fc fragments of immunoglobulin. II. Augmentation of the cell-mediated lympholysis response occurs through an Lyt-1+2- helper T cell.免疫球蛋白Fc片段对T淋巴细胞功能的增强作用。II. 通过Lyt-1+2-辅助性T细胞增强细胞介导的淋巴细胞溶解反应。
J Immunol. 1981 Dec;127(6):2526-30.
3
Regulation of the in vitro presentation of minor lymphocyte stimulating determinants by major histocompatibility complex-encoded immune response genes.主要组织相容性复合体编码的免疫应答基因对次要淋巴细胞刺激决定簇体外呈递的调控。
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4
Potentiation of specific human in vitro immune responses by the Fc portion of human immunoglobulin.人免疫球蛋白Fc部分对特定人体外免疫反应的增强作用。
Clin Exp Immunol. 1983 Aug;53(2):505-11.
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Distinctive functional properties of human blood L lymphocytes: a comparison with T lymphocytes, B lymphocytes, and monocytes.人血L淋巴细胞独特的功能特性：与T淋巴细胞、B淋巴细胞及单核细胞的比较。
J Immunol. 1977 May;118(5):1712-21.
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Activation of T lymphocytes by the Fc portion of immunoglobulin.免疫球蛋白Fc部分对T淋巴细胞的激活。
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Immunopharmacology. 1988 Mar-Apr;15(2):73-84. doi: 10.1016/0162-3109(88)90054-9.
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Heterogeneity of stimulator cells in the murine mixed leukocyte response.小鼠混合淋巴细胞反应中刺激细胞的异质性。
Eur J Immunol. 1982 Jan;12(1):9-15. doi: 10.1002/eji.1830120105.
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Immunological properties of Fc receptor on lymphocytes. 3. Stimulating activities of Fc receptor-bearing and -nonbearing cells in mixed-lymphocyte reaction.淋巴细胞上Fc受体的免疫学特性。3. 混合淋巴细胞反应中带有Fc受体和不带有Fc受体细胞的刺激活性。
Cell Immunol. 1978 Feb;35(2):279-88. doi: 10.1016/0008-8749(78)90149-1.
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The receptor specificity of alloreactive T cells. Distinction between stimulator K, I, and D region products and degeneracy of third-party H-2 recognition by low-affinity T cells.同种异体反应性T细胞的受体特异性。刺激细胞K、I和D区产物之间的区别以及低亲和力T细胞对第三方H-2识别的简并性。
J Exp Med. 1979 Dec 1;150(6):1520-37. doi: 10.1084/jem.150.6.1520.

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Clin Exp Immunol. 1983 Aug;53(2):505-11.
4
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本文引用的文献

1
The hydrolysis of rabbit y-globulin and antibodies with crystalline papain.用结晶木瓜蛋白酶对兔γ球蛋白和抗体进行水解。
Biochem J. 1959 Sep;73(1):119-26. doi: 10.1042/bj0730119.
2
Regulation of the immune response. II. Characterization of the cell population(s) involved in the Fc fragment-induced adjuvant effect.免疫反应的调节。II. 参与Fc片段诱导的佐剂效应的细胞群体的特性。
J Immunol. 1980 Sep;125(3):1275-9.
3
Regulation of the immune response. I. The potentiation of in vivo and in vitro immune responses by Fc fragments.免疫反应的调节。I. Fc片段对体内和体外免疫反应的增强作用。
J Exp Med. 1980 Jul 1;152(1):113-23. doi: 10.1084/jem.152.1.113.
4
Fc fragment activation of T lymphocytes. I. Fc fragments trigger Lyt 1+23- T lymphocytes to release a helper T cell-replacing activity.T淋巴细胞的Fc片段激活。I. Fc片段触发Lyt 1+23- T淋巴细胞释放一种替代辅助性T细胞的活性物质。
J Immunol. 1981 Feb;126(2):632-5.
5
Polyclonal activation of murine B lymphocytes by Fe fragments. II. Replacement of T cells by a soluble helper T cell-replacing factor (TRF).铁片段对小鼠B淋巴细胞的多克隆激活。II. 用可溶性辅助性T细胞替代因子（TRF）替代T细胞
J Immunol. 1980 Oct;125(4):1630-3.
6
Polyclonal activation of murine B lymphocytes by Fc fragments. I. The requirement for two signals in the generation of the polyclonal antibody response induced by Fc fragments.Fc片段对小鼠B淋巴细胞的多克隆激活。I. Fc片段诱导多克隆抗体反应产生中两个信号的需求。
J Immunol. 1980 Mar;124(3):1330-5.
7
Regulation of Fc fragment-induced murine spleen cell proliferation.Fc片段诱导的小鼠脾细胞增殖的调控
J Exp Med. 1980 Jan 1;151(1):1-11. doi: 10.1084/jem.151.1.1.
8
The differentiation of cytotoxic T cells in vitro. II. Amplifying factor(s) produced in primary mixed lymphocyte cultures against K/D stimuli require the presence of Lyt 2+ cells but not Lyt 1+ cells.细胞毒性T细胞的体外分化。II. 针对K/D刺激在初次混合淋巴细胞培养物中产生的扩增因子需要Lyt 2+细胞存在，但不需要Lyt 1+细胞。
J Immunol. 1980 Jul;125(1):300-7.
9
I-N: a newly described H-2 I subregion between K and I-A.I-N：K和I-A之间新描述的H-2 I亚区。
J Exp Med. 1980 Feb 1;151(2):481-5. doi: 10.1084/jem.151.2.481.
10
A rapid method for the isolation of functional thymus-derived murine lymphocytes.一种分离功能性胸腺来源的小鼠淋巴细胞的快速方法。
Eur J Immunol. 1973 Oct;3(10):645-9. doi: 10.1002/eji.1830031011.