Rodrigo G, Lusiardo M, Briggs G, Ulmer A
Department of Family Medicine, University of Mississippi Medical Center, Jackson.
Acta Psychiatr Scand. 1992 Nov;86(5):327-31. doi: 10.1111/j.1600-0447.1992.tb03274.x.
Prior reviews indicate that schizophrenics tend to be born in the winter, relative to non-psychiatric controls. This conclusion has been criticized, however, as the association between birth seasonality and schizophrenia may be the result of a statistical artifact, the age-incidence effect. To examine this possibility, we studied the birth seasonality of 2892 schizophrenics, controlling for the age-incidence effect. Both before and after instituting these controls, we found excesses for the months of December and March. We conclude that the age-incidence hypothesis does not provide any general explanation of the season-of-birth effect in schizophrenia.
先前的综述表明，相对于非精神疾病对照人群，精神分裂症患者往往出生在冬季。然而，这一结论受到了批评，因为出生季节性与精神分裂症之间的关联可能是一种统计假象，即年龄发病率效应的结果。为了检验这种可能性，我们研究了2892名精神分裂症患者的出生季节性，并对年龄发病率效应进行了控制。在采取这些控制措施之前和之后，我们都发现12月和3月的患者人数过多。我们得出结论，年龄发病率假说并不能对精神分裂症的出生季节效应提供任何一般性解释。
