Peltz S W, Jacobson A
University of Massachusetts Medical School, Worcester.
Curr Opin Cell Biol. 1992 Dec;4(6):979-83. doi: 10.1016/0955-0674(92)90129-z.
The regulation of mRNA stability is an important step in the control of gene expression. Characterization of the mechanisms involved in the turnover of individual mRNAs has identified a requirement for specific cis-acting sequences and trans-acting factors, as well as an involvement of the translation apparatus. In the past year, significant progress has been made in the identification of trans-acting factors by both biochemical and genetic approaches. This review summarizes that progress and promotes the notion that the ribosome itself should also be considered as a trans-acting component of the mRNA decay machinery.
mRNA稳定性的调控是基因表达控制中的一个重要步骤。对单个mRNA周转所涉及机制的表征已确定了对特定顺式作用序列和反式作用因子的需求，以及翻译装置的参与。在过去的一年里，通过生化和遗传方法在鉴定反式作用因子方面取得了重大进展。本综述总结了这一进展，并提出核糖体本身也应被视为mRNA降解机制的反式作用成分这一观点。
