Collantes Estevéz E, Tinahones Madueño F J, González Ruiz A, Añón Barbudo J, Pineda Priego M, Sánchez Guijo P
Clin Rheumatol. 1992 Dec;11(4):498-501. doi: 10.1007/BF02283105.
We studied the renal urate excretory function in two groups of hyperuricaemic male patients composed of individuals with associated hyperlipidemia and hyperuricaemic-normolipidemic individuals, respectively. Both the hyperlipidemia and the hyperuricaemia were primary inasmuch as none of the patients studied was obese or had an above-normal alcohol intake or blood hypertension. The results obtained show that hyperuricaemic-hyperlipidemic patients have higher serum levels of uric acid and poorer urate excretion as reflected in smaller clearance and fractioned excretion of the metabolite than hyperuricaemic-normolipidemic patients. This, in turn, suggests the occurrence of differences in the extent of the urate handling anomalies between the two groups of patients.
我们分别对两组高尿酸血症男性患者的肾脏尿酸排泄功能进行了研究，一组伴有高脂血症，另一组为高尿酸血症-血脂正常个体。高脂血症和高尿酸血症均为原发性，因为所研究的患者均无肥胖、饮酒量高于正常或高血压情况。所得结果表明，与高尿酸血症-血脂正常患者相比，高尿酸血症-高脂血症患者的血清尿酸水平更高，尿酸排泄更差，这体现在该代谢物的清除率和分数排泄较小。这反过来表明两组患者在尿酸处理异常程度上存在差异。
