Department of Nursing, Min-Hwei Junior College of Health Care Management, Tainan City 736, Taiwan.
BMC Public Health. 2013 Dec 5;13:1136. doi: 10.1186/1471-2458-13-1136.
Studies have associated betel nut chewing with cancers, metabolic syndrome, cardiovascular disorders, chronic kidney disease, and proteinuria. This study investigated whether hyperuricemia is associated with betel nut chewing in men who participated in a health check-up program.
From hospital records, we identified a total of 11,991 men who participated in the health check-up program from 2003 to 2009. They were divided into hyperuricemic group and non-hyperuricemic group. Laboratory tests, medical history, and status of cigarette smoking, alcohol consumption, and betel nut chewing were compared between the 2 groups. We calculated odds ratio (OR) and 95% confidence interval (CI) of hyperuricemia in association with betel nut consumption and other factors.
Compared with the non-hyperuricemic group, the hyperuricemic group was slightly older (59.4 vs. 58.6 years) but less prevalent with betel nut use (11.8 vs. 13.6%, p = 0.003). Multivariable logistic regression analysis showed that hyperuricemia was negatively associated with betel nut chewing (OR 0.75, 95% CI 0.66-0.84), older age (OR 0.84, 95% CI 0.77-0.93), and diabetes mellitus (OR 0.57, 95% CI 0.50-0.64). On the other hand, hyperuricemia was positively associated with body mass index (OR 1.75, 95% CI 1.62-1.90), drinking (OR 1.36, 95% CI 1.25-1.49), hypertension (OR 1.41, 95% CI 1.30-1.52), mixed hyperlipidemia (OR 1.84, 95% CI 1.33-2.54), chronic kidney disease (OR 3.28, 95% CI 2.94-3.65), and proteinuria (OR 1.22, 95% CI 1.08-1.38). Smoking, hypercholesterolemia, and hypertriglyceridemia had no significant association with hyperuricemia.
Our data suggest that betel nut chewing is negatively associated with hyperuricemia.
研究表明，嚼槟榔与癌症、代谢综合征、心血管疾病、慢性肾脏病和蛋白尿有关。本研究旨在探讨在参加健康体检计划的男性中，高尿酸血症是否与嚼槟榔有关。
我们从医院记录中确定了 2003 年至 2009 年期间共有 11991 名参加健康体检计划的男性。他们被分为高尿酸血症组和非高尿酸血症组。比较两组之间的实验室检查、病史以及吸烟、饮酒和嚼槟榔的情况。我们计算了与槟榔消费和其他因素相关的高尿酸血症的比值比（OR）和 95%置信区间（CI）。
与非高尿酸血症组相比，高尿酸血症组年龄稍大（59.4 岁比 58.6 岁），但嚼槟榔的比例较低（11.8%比 13.6%，p=0.003）。多变量 logistic 回归分析显示，高尿酸血症与嚼槟榔呈负相关（OR 0.75，95%CI 0.66-0.84），与年龄较大（OR 0.84，95%CI 0.77-0.93）和糖尿病（OR 0.57，95%CI 0.50-0.64）有关。另一方面，高尿酸血症与体重指数（OR 1.75，95%CI 1.62-1.90）、饮酒（OR 1.36，95%CI 1.25-1.49）、高血压（OR 1.41，95%CI 1.30-1.52）、混合性高脂血症（OR 1.84，95%CI 1.33-2.54）、慢性肾脏病（OR 3.28，95%CI 2.94-3.65）和蛋白尿（OR 1.22，95%CI 1.08-1.38）呈正相关。吸烟、高胆固醇血症和高三酰甘油血症与高尿酸血症无显著相关性。
我们的数据表明，嚼槟榔与高尿酸血症呈负相关。
