Collantes E, Tinahones F J, Cisnal A, Añon J, Sanchez-Guijo P
Department of Medicine, University of Córdoba, Spain.
Clin Rheumatol. 1994 Jun;13(2):244-7. doi: 10.1007/BF02249020.
We studied changes in the hyperuricaemia-associated lipid phenotypes of primary hyperuricaemic-hyperlipidemic patients, none of whom was obese, hypertensive or an alcohol drinker. The patients were monitored for three months during which they were placed on a strict diet. The results obtained showed that phenotype IIB was most frequently associated with hyperuricaemia, followed by phenotypes IV and IIA. Lipid phenotypes were found to change in most patients during the study, even though most of them remained hyperuricaemic-hyperlipidemic. We also determined apoprotein B in each determination and found that over half the patients possessed increased levels of this apolipoprotein. The results confirm that hyperuricaemia is not associated to a unique lipid phenotype since the phenotype of a given patient may change with time, even in the absence of propitiating external factors.
我们研究了原发性高尿酸血症合并高脂血症患者（均非肥胖、高血压或饮酒者）与高尿酸血症相关的脂质表型变化。对这些患者进行了为期三个月的监测，在此期间让他们严格节食。获得的结果显示，IIB型脂质表型与高尿酸血症的关联最为频繁，其次是IV型和IIA型。研究发现，大多数患者的脂质表型在研究期间发生了变化，尽管他们中的大多数人仍为高尿酸血症合并高脂血症。我们还在每次检测中测定了载脂蛋白B，发现超过半数的患者该载脂蛋白水平升高。结果证实，高尿酸血症并非与单一脂质表型相关，因为即使在没有促发外部因素的情况下，特定患者的表型也可能随时间而改变。
