Baxendale Ian R, Hayward John J, Ley Steven V
Innovative Technology Centre (ACS), Department of Chemistry, Lensfield Road, Cambridge, UK.
Comb Chem High Throughput Screen. 2007 Dec;10(10):802-36. doi: 10.2174/138620707783220374.
Microwave chemistry has already impacted significantly on the everyday synthesis of organic molecules. The adoption and integration of this liberating technology has permitted a resurrection of many synthetic transformations that were previously considered too extreme in their conditions (temperatures, pressures, reaction times) to be synthetically useful. Furthermore, whole arrays of additional chemical transformations have been devised under microwave heating that allow access to more diverse chemical architectures via more expedient routes. Continuous flow processing of chemical intermediates taking advantage of the unique heating mechanism and characteristics of microwave irradiation will certainly be the next evolutionary step forward in this area. The synergistic combination afforded by the simultaneous application of these two core processing tools will enhance still further the synthetic capabilities of tomorrow's chemists. This short review aims to highlight the current developments and future potential offered by continuous flow microwave mediated synthesis.
微波化学已经对有机分子的日常合成产生了重大影响。这种解放性技术的采用和整合使得许多以前因其条件（温度、压力、反应时间）过于极端而被认为在合成上无用的合成转化得以复兴。此外，在微波加热条件下还设计出了一系列额外的化学转化方法，从而能够通过更便捷的途径获得更多样化的化学结构。利用微波辐射独特的加热机制和特性对化学中间体进行连续流动处理，必将成为该领域下一步的发展方向。同时应用这两种核心处理工具所带来的协同组合，将进一步提升未来化学家的合成能力。这篇简短的综述旨在突出连续流动微波介导合成的当前进展和未来潜力。
