Nüchter Matthias, Ondruschka Bernd
Institute of Technical Chemistry and Environmental Chemistry, Friedrich Schiller University Jena, Lessingstr 12, D-07743 Jena, Germany.
Mol Divers. 2003;7(2-4):253-64. doi: 10.1023/b:modi.0000006916.69862.3d.
A protocol for transferring conventional reactions to the microwave field explores the effectiveness of parallel syntheses and combination approaches. Applicability to the reaction systems combiCHEM, multiPREP, MMR8 and HPR is defined. Model reactions have been performed in laboratory equipment. Emphasis is placed on similar reaction conditions in the individual vessels and the repeatability of results. Outcomes include esterifications and multi-center reactions exhibiting a great potential for combinatorial chemistry.
一种将传统反应转移至微波场的方案探索了平行合成及组合方法的有效性。定义了其对combiCHEM、multiPREP、MMR8和HPR反应体系的适用性。已在实验室设备中进行了模型反应。重点在于各个反应容器中相似的反应条件以及结果的可重复性。成果包括酯化反应和多中心反应，这些反应在组合化学方面展现出巨大潜力。
