干细胞可塑性：从转分化到巨噬细胞融合
Stem cell plasticity: from transdifferentiation to macrophage fusion.
作者信息
Camargo F D, Chambers S M, Goodell M A
机构信息
Interdepartmental Program in Cell and Molecular Biology, Center for Cell and Gene Therapy, Baylor College of Medicine, Houston, TX 77098, USA.
出版信息
Cell Prolif. 2004 Feb;37(1):55-65. doi: 10.1111/j.1365-2184.2004.00300.x.
Abstract
The past 5 years have witnessed an explosion of interest in using adult-derived stem cells for cell and gene therapy. This has been driven by a number of findings, in particular, the possibility that some adult stem cells can differentiate into non-autologous cell types, and also the discovery of multipotential stem cells in adult bone marrow. These discoveries suggested a quasi-alchemical nature of cells derived from adult organs, thus raising new and exciting therapeutic possibilities. Recent data, however, argue against the whole idea of stem cell 'plasticity', and bring into question the therapeutic strategies based upon this concept. Here, we will review the current state of knowledge in the field and discuss some of the clinical implications.
摘要
在过去五年中，人们对使用成人来源的干细胞进行细胞和基因治疗的兴趣激增。这一现象是由一系列研究结果推动的，特别是一些成人干细胞能够分化为非自体细胞类型的可能性，以及在成人骨髓中发现多能干细胞。这些发现表明源自成人器官的细胞具有一种类似炼金术的特性，从而带来了全新且令人兴奋的治疗可能性。然而，最近的数据对干细胞“可塑性”这一整体概念提出了质疑，并使基于该概念的治疗策略受到质疑。在此，我们将回顾该领域的当前知识状况，并讨论一些临床意义。
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