Wong F L, Kodama K, Sasaki H, Yamada M, Hamilton H B
Department of Statistics, Radiation Effects Research Foundation, Hiroshima, Japan.
Genet Epidemiol. 1992;9(6):405-18. doi: 10.1002/gepi.1370090604.
The relationship between ABO blood phenotype and total serum cholesterol (TC) level was examined in a Japanese population to determine whether an elevated TC level is associated with phenotype A, as has been demonstrated in many West European populations. Such studies in nonwhite populations are scarce, and findings generally failed to demonstrate the relationship. Inconsistent results from cross-sectional studies of various racial groups with widely varying ages raised an age effect as a possible explanatory factor. It was also suggested that the ABO-TC association may not be apparent in populations with low fat intake or low mean cholesterol level. These hypotheses are addressed by examining long-term TC data collected serially from the unexposed controls of the atomic bomb survivors in Hiroshima and Nagasaki who were participants of the Adult Health Study program at the Atomic Bomb Casualty Commission-Radiation Effects Research Foundation between 1958 and 1986. The statistical method of growth curve analysis, through the mixed effect model of Laird and Ware [1982], was used to model age-dependent changes in cholesterol levels within individuals. The effects of the ABO polymorphism in modifying the resultant growth curve are examined. We demonstrate that TC levels are elevated on average by about 4 mg/dl in phenotype A compared to non-A in the Japanese (P < 0.00001), and that this relationship is maintained from early to late adulthood, independent of sex, body mass index, cohort status, or city of residence. Thus, phenotype A individuals may be more predisposed to cardiovascular disease through one of its major risk factors. This is the first study of the ABO-cholesterol association in the Japanese, and the first based on a cohort with longitudinally collected TC data.
在日本人群中研究了ABO血型表型与血清总胆固醇（TC）水平之间的关系，以确定TC水平升高是否与A型表型相关，正如在许多西欧人群中所证实的那样。在非白人人群中进行的此类研究很少，而且研究结果通常未能证明这种关系。对不同年龄的各种种族群体进行的横断面研究结果不一致，这表明年龄效应可能是一个解释因素。也有人提出，在脂肪摄入量低或平均胆固醇水平低的人群中，ABO与TC的关联可能不明显。通过检查1958年至1986年期间参加原子弹伤亡委员会-辐射效应研究基金会成人健康研究项目的广岛和长崎原子弹爆炸幸存者未暴露对照组连续收集的长期TC数据，对这些假设进行了验证。采用Laird和Ware [1982]的混合效应模型，通过生长曲线分析的统计方法，对个体内胆固醇水平随年龄的变化进行建模。研究了ABO多态性对所得生长曲线的影响。我们证明，与非A型日本人相比，A型日本人的TC水平平均升高约4mg/dl（P < 0.00001），并且这种关系从成年早期到晚期都保持不变，与性别、体重指数、队列状态或居住城市无关。因此，A型个体可能通过其主要危险因素之一更容易患心血管疾病。这是首次在日本人中研究ABO与胆固醇的关联，也是首次基于纵向收集TC数据的队列研究。
