硝苯地平对正常血压和自发性高血压大鼠胎盘血流、胎盘重量及胎儿体重的影响。
Effects of nifedipine on placental blood flow, placental weight and fetal weight in normotensive and spontaneously hypertensive rats.
作者信息
Furuhashi N, Tsujiei M, Kimura H, Nagae H, Yajima A
机构信息
Department of Obstetrics and Gynecology, Tohoku University, School of Medicine, Sendai, Japan.
出版信息
Gynecol Obstet Invest. 1992;34(4):193-6. doi: 10.1159/000292759.
The effect of nifedipine on placental blood flow was investigated in spontaneously hypertensive rats (SHR) and compared with that in normotensive Wistar Kyoto rats (WKY) by means of the clearance of hydrogen gas generated by electrolysis. The placental blood flow of nifedipine-treated WKY (5, 10 and 25 mg/kg) was significantly (p < 0.05) reduced compared with that of WKY control. On the other hand, the placental blood flow of nifedipine-treated SHR did not change compared with that of SHR control. These data suggest that nifedipine has different effects on placental blood flow in SHR and WKY.
通过电解产生的氢气清除率，研究了硝苯地平对自发性高血压大鼠（SHR）胎盘血流的影响，并与正常血压的Wistar Kyoto大鼠（WKY）进行了比较。与WKY对照组相比，硝苯地平处理的WKY（5、10和25mg/kg）的胎盘血流显著降低（p<0.05）。另一方面，与SHR对照组相比，硝苯地平处理的SHR的胎盘血流没有变化。这些数据表明，硝苯地平对SHR和WKY的胎盘血流有不同的影响。
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