硝苯地平对正常血压大鼠胎盘血流、胎盘重量和胎儿体重的影响。
Effects of nifedipine on normotensive rat placental blood flow, placental weight and fetal weight.
作者信息
Furuhashi N, Tsujiei M, Kimura H, Yajima A
机构信息
Department of Obstetrics and Gynecology, Tohoku University, School of Medicine, Sendai, Japan.
出版信息
Gynecol Obstet Invest. 1991;32(1):1-3. doi: 10.1159/000292979.
Recently, nifedipine (Ca antagonist) has been used for the treatment of preeclampsia. In this study, we investigated the effects of nifedipine on the normotensive Wistar Kyoto rat's placental blood flow, fetal weight and placental weight. We measured the rat's placental blood flow using clearance of hydrogen gas generated by electrolysis. The placental blood flow, placental and fetal weights of nifedipine-treated rats (5, 10 and 25 mg/kg) were significantly (p less than 0.05) reduced compared with normal pregnant rats. These data suggest that nifedipine might have some reducing effects on placental blood flow, fetal weight and placental weight.
最近，硝苯地平（钙拮抗剂）已被用于治疗先兆子痫。在本研究中，我们调查了硝苯地平对血压正常的Wistar Kyoto大鼠胎盘血流量、胎儿体重和胎盘重量的影响。我们使用电解产生的氢气清除率来测量大鼠的胎盘血流量。与正常妊娠大鼠相比，硝苯地平治疗组大鼠（5、10和25mg/kg）的胎盘血流量、胎盘和胎儿重量均显著降低（p<0.05）。这些数据表明，硝苯地平可能对胎盘血流量、胎儿体重和胎盘重量有一定的降低作用。
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