酮色林（一种血清素受体拮抗剂）对自发性高血压大鼠和正常Wistar Kyoto大鼠胎盘血流量、胎盘重量及胎儿体重的影响。

Effects of ketanserin--a serotonin receptor antagonist--on placental blood flow, placental weight and fetal weight of spontaneously hypertensive rats and normal Wistar Kyoto rats.

作者信息

Furuhashi N, Tsujiei M, Kimura H, Yajima A

机构信息

Department of Obstetrics and Gynecology, Tohoku University, School of Medicine, Sendai, Japan.

出版信息

Gynecol Obstet Invest. 1991;32(2):65-7. doi: 10.1159/000292996.

DOI:10.1159/000292996

PMID:1748324

Abstract

Recently, ketanserin (serotonin receptor antagonist) has been reported to be beneficial in the treatment of preeclampsia. In this study, we investigated the effects of ketanserin on the placental blood flow, fetal weight and placental weight in spontaneously hypertensive rats (SHR) and normotensive Wistar Kyoto rats (WKY). We measured the rats' placental blood flow by monitoring the clearance of hydrogen gas generated by electrolysis. In ketanserin (12, 24, 48 mg/kg)-treated SHR, systolic blood pressure was significantly decreased. The placental blood flow was significantly (p less than 0.05) reduced compared to that before treatment in WKY and SHR. The fetal weight decreased dose dependently in WKY, while in SHR it did not decrease significantly. The placental weight of ketanserin-treated rats decreased compared to that before treatment. These data suggest that ketanserin might have some reducing effects on placental blood flow, fetal weight and placental weight proportional to the dose.

摘要

最近，有报道称酮色林（血清素受体拮抗剂）在子痫前期的治疗中有益。在本研究中，我们调查了酮色林对自发性高血压大鼠（SHR）和血压正常的Wistar Kyoto大鼠（WKY）的胎盘血流量、胎儿体重和胎盘重量的影响。我们通过监测电解产生的氢气清除率来测量大鼠的胎盘血流量。在接受酮色林（12、24、48毫克/千克）治疗的SHR中，收缩压显著降低。与治疗前相比，WKY和SHR的胎盘血流量均显著降低（p<0.05）。WKY的胎儿体重呈剂量依赖性下降，而SHR的胎儿体重无显著下降。与治疗前相比，接受酮色林治疗的大鼠胎盘重量下降。这些数据表明，酮色林可能对胎盘血流量、胎儿体重和胎盘重量具有与剂量成比例的降低作用。