血栓素合成酶抑制剂（OKY - 046）对正常血压和自发性高血压大鼠胎盘血流、胎盘重量及胎儿体重的影响。

Effects of thromboxane synthetase inhibitor (OKY-046) on placental blood flow, placental weight and fetal weight in normotensive and spontaneously hypertensive rats.

作者信息

Furuhashi N, Tsujiei M, Kimura H, Nagae H, Yajima A

机构信息

Department of Obstetrics and Gynecology, Tohoku University, School of Medicine, Sendai, Japan.

出版信息

Gynecol Obstet Invest. 1993;35(1):23-6. doi: 10.1159/000292657.

DOI:10.1159/000292657

PMID:8449429

Abstract

Recently, thromboxane synthetase inhibitor has been used for the treatment of preeclampsia. In this study, we investigated the effects of thromboxane synthetase inhibitor (OKY-046) on placental blood flow (measured with clearance of hydrogen gas generated by electrolysis) in normotensive Wistar-Kyoto rats (WKY) and spontaneously hypertensive rats (SHR). The systolic blood pressure of OKY-046-treated SHR (1, 4 and 8 mg/kg) decreased significantly (p < 0.05); however, the systolic blood pressure of WKY did not decrease. The placental blood flow of both OKY-046-treated WKY and SHR did not decrease. We found that OKY-046 has no reducing effect on placental blood flow in rats, and systolic blood pressure of SHR decreases. These data suggest that thromboxane synthetase inhibitor might have a beneficial effect on preeclampsia.

摘要

最近，血栓素合成酶抑制剂已被用于治疗子痫前期。在本研究中，我们研究了血栓素合成酶抑制剂（OKY - 046）对正常血压的Wistar - Kyoto大鼠（WKY）和自发性高血压大鼠（SHR）胎盘血流量（通过电解产生的氢气清除率测量）的影响。经OKY - 046治疗的SHR（1、4和8 mg/kg）的收缩压显著降低（p < 0.05）；然而，WKY的收缩压并未降低。经OKY - 046治疗的WKY和SHR的胎盘血流量均未降低。我们发现OKY - 046对大鼠胎盘血流量没有降低作用，但SHR的收缩压降低。这些数据表明，血栓素合成酶抑制剂可能对子痫前期有有益作用。