Murphy D A, Pelham W E, Lang A R
Department of Psychiatry and Mental Health Science, Medical College of Wisconsin, Milwaukee 53226.
J Abnorm Child Psychol. 1992 Oct;20(5):451-66. doi: 10.1007/BF00916809.
High and low-aggressive boys with attention deficit-hyperactivity disorder (ADHD) were compared and the effects of methylphenidate were examined on measures from three domains of aggression: (1) directly observed verbal and nonverbal aggressive behaviors exhibited in the context of a day treatment program, (2) aggressive responding when provoked during a laboratory task, and (3) social information processing patterns exhibited on tasks designed to tap the putative cognitive components of aggression. The high-aggressive (HA) and low-aggressive (LA) subgroups differed significantly on observational measures of aggression and on the laboratory provocation task, but the HA group showed more deviant cognitions on only one of the numerous measures of social information processing. Regarding medication effects on the direct observation measures, methylphenidate decreased aggression for both subgroups. On the laboratory provocation task, methylphenidate had only minimal effects. Significant drug effects were obtained on only two recall social information processing measures.
对患有注意力缺陷多动障碍（ADHD）的高攻击性和低攻击性男孩进行了比较，并研究了哌甲酯对攻击行为三个方面指标的影响：（1）在日间治疗项目中直接观察到的言语和非言语攻击行为；（2）在实验室任务中受到挑衅时的攻击反应；（3）在旨在挖掘攻击行为假定认知成分的任务中表现出的社会信息处理模式。高攻击性（HA）和低攻击性（LA）亚组在攻击行为的观察指标和实验室挑衅任务上存在显著差异，但HA组仅在众多社会信息处理指标中的一项上表现出更多异常认知。关于药物对直接观察指标的影响，哌甲酯使两个亚组的攻击行为均减少。在实验室挑衅任务中，哌甲酯仅有极小的影响。仅在两项回忆社会信息处理指标上获得了显著的药物效果。
