Bense L, Eklund G, Wiman L G
Department of Pulmonary Medicine, Huddinge University Hospital, Sweden.
Am Rev Respir Dis. 1992 Aug;146(2):513-6. doi: 10.1164/ajrccm/146.2.513.
Flexible fiberoptic bronchoscopy (FFB) was performed in 26 never-smokers with healed spontaneous pneumothorax (SP) with the aim of detecting and localizing any bronchial obstruction, including congenital anomaly. In a case-control study these patients were compared with a consecutive, randomly sampled, control group of 41 patients who were undergoing FFB for respiratory symptoms but who had not had a SP. In both groups the endobronchial anatomy with respect to such anomalies, which could be classified as disproportionate bronchial anatomy, an accessory bronchus, and/or a missing bronchus, was compared with normal anatomy. All except one of the 26 patients with SP but only four of the 41 control patients without SP had such bronchial anomalies bilaterally. This corresponds to an odds ratio of 231 (95% confidence interval, 24 to 880; p < 0.001). The significantly higher frequency of bilateral bronchial anomalies in never-smokers with SP suggests that a virtual prerequisite for the occurrence of SP has been found. However causal links between the probably congenital bronchial anomalies and SP have not yet been identified.
对26例已治愈的特发性气胸（SP）非吸烟患者进行了可弯曲纤维支气管镜检查（FFB），目的是检测和定位任何支气管阻塞，包括先天性异常。在一项病例对照研究中，将这些患者与41例因呼吸道症状接受FFB但未患过SP的连续随机抽样对照组患者进行比较。在两组中，将与可归类为支气管解剖结构不成比例、副支气管和/或支气管缺失等异常相关的支气管内解剖结构与正常解剖结构进行比较。26例SP患者中除1例外，其余均有双侧支气管异常，而41例无SP的对照患者中只有4例有双侧支气管异常。这对应于优势比为231（95%置信区间，24至880；p<0.001）。SP非吸烟患者双侧支气管异常的频率显著更高，这表明已发现SP发生的一个几乎先决条件。然而，尚未确定可能的先天性支气管异常与SP之间的因果关系。
