聚天冬氨酸对实验性庆大霉素肾毒性的保护作用持续时间。
Duration of the protective effect of polyaspartic acid on experimental gentamicin nephrotoxicity.
作者信息
Swan S K, Gilbert D N, Kohlhepp S J, Leggett J E, Kohnen P W, Bennett W M
机构信息
Division of Nephrology, Oregon Health Sciences University, Portland 97201.
出版信息
Antimicrob Agents Chemother. 1992 Nov;36(11):2556-8. doi: 10.1128/AAC.36.11.2556.
Abstract
It is known that daily polyaspartic acid (PAA) protects the kidney from gentamicin nephrotoxicity in a standardized rat model despite marked cortical accumulation of the aminoglycoside. The present experiments address the duration of PAA protection. When administered every other day, PAA provided functional and histologic protection against gentamicin-induced toxicity. A stepwise reduction in nephroprotection occurred as the dosage interval was prolonged.
摘要
已知在标准化大鼠模型中，每日给予聚天冬氨酸（PAA）可保护肾脏免受庆大霉素肾毒性影响，尽管氨基糖苷类药物在皮质有明显蓄积。本实验探讨了PAA保护作用的持续时间。隔日给予PAA可提供针对庆大霉素诱导毒性的功能和组织学保护。随着给药间隔延长，肾保护作用逐步减弱。
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