Swan S K, Gilbert D N, Kohlhepp S J, Kohnen P W, Bennett W M
Division of Nephrology, Hypertension, and Clinical Pharmacology, Oregon Health Sciences, Portland 92701.
Antimicrob Agents Chemother. 1993 Feb;37(2):347-8. doi: 10.1128/AAC.37.2.347.
Polyaspartic acid (PAA) ameliorates experimental gentamicin nephrotoxicity despite marked accumulation of gentamicin in the renal cortex. The experiments described here probe the extent of PAA's nephroprotective action when increasing doses of gentamicin, in excess of an established nephrotoxic dose (40 mg/kg of body weight per day), are administered. After 10 days, virtually complete nephroprotection was conferred by PAA coadministered to animals receiving three times the nephrotoxic dose (120 mg/kg/day) of gentamicin.
尽管庆大霉素在肾皮质中显著蓄积，但聚天冬氨酸（PAA）仍可改善实验性庆大霉素肾毒性。本文所述实验探究了在给予超过既定肾毒性剂量（每天40mg/kg体重）的递增剂量庆大霉素时，PAA的肾保护作用程度。10天后，对于接受三倍肾毒性剂量（120mg/kg/天）庆大霉素的动物，联合给予PAA几乎可提供完全的肾保护。
