Bose S, Ghosh P, Ghosh S, Chaudhury S, Bhattacharya S
Department of Zoology, Visva-Bharati University, Santiniketan, India.
Biomed Environ Sci. 1992 Dec;5(4):355-61.
The distribution of mercury, an environmentally important toxicant, has been evaluated in a time dependent manner in different tissues of white rat and a freshwater teleost, Anabas testudineus. Sampling was performed at 15 min, 2, 6 and 48 h post injection (im) of 203Hg mercuric nitrate. Radioactivity of the 5% tissue homogenate, serum and bile was measured in a Gamma Counter. The rate of 203Hg accumulation is higher in fish immediately after administration which, however, is more or less of equal rate in the later period of observation in both the experimental animals. Partitioning of 203Hg occurs in a species specific manner with higher levels recorded in the brain and gonad of white rat. Spleen, liver and kidney, however, are the major tissues to accumulate mercury in both the species. The present study highlights that kidney is the target site of mercury retention with a higher kidney/liver ratio of mercury.
汞是一种对环境具有重要影响的有毒物质，本研究以时间依赖的方式评估了汞在白鼠和淡水硬骨鱼攀鲈不同组织中的分布情况。在注射203Hg硝酸汞后15分钟、2小时、6小时和48小时（腹腔注射）进行取样。在伽马计数器中测量5%组织匀浆、血清和胆汁的放射性。给药后，汞在鱼体内的积累速率立即升高，但在两种实验动物观察后期，其积累速率大致相等。203Hg的分配呈现物种特异性，白鼠的大脑和性腺中汞含量较高。然而，在这两个物种中，脾脏、肝脏和肾脏是积累汞的主要组织。本研究强调，肾脏是汞潴留的靶器官，肾脏与肝脏的汞含量比值较高。
