Bootz F, Reuter G
Department of Otorhinolaryngology, University of Tübingen, Federal Republic of Germany.
Eur Arch Otorhinolaryngol. 1992;249(7):359-63. doi: 10.1007/BF00192254.
Following free grafting of septal mucosa from the rat to the rectus abdominis muscle, the mucosal membrane was found to degenerate into a flat squamous epithelium with loss of the majority of differentiated epithelial cells. Both the goblet cells and ciliated cells regenerated from stem cells, which appear in large numbers 2 days after transplantation. Microvilli were found initially on the surfaces of developing ciliated cells and were replaced 21 days post-grafting by cilia. The number of goblet cells during regeneration at first exceeded that of the ciliated cells, but decreased with the passage of time. After 4 months there were more ciliated cells, with the respiratory epithelium now appearing no different than the initially transplanted nasal mucosa.
将大鼠鼻中隔黏膜游离移植到腹直肌后，发现黏膜膜退化为扁平鳞状上皮，大多数分化的上皮细胞丢失。杯状细胞和纤毛细胞均从干细胞再生，这些干细胞在移植后2天大量出现。微绒毛最初出现在发育中的纤毛细胞表面，并在移植后21天被纤毛取代。再生过程中杯状细胞的数量起初超过纤毛细胞，但随着时间的推移而减少。4个月后，纤毛细胞增多，此时呼吸道上皮与最初移植的鼻黏膜无异。
