Engelen A M, Stalpers L J, Manni J J, Ruijs J H, van Daal W A
Department of Radiotherapy, Nijmegen University Hospital St. Radboud, The Netherlands.
Eur Arch Otorhinolaryngol. 1992;249(7):364-9. doi: 10.1007/BF00192255.
In a retrospective study of 556 patients (505 men, 51 women) with laryngeal cancer the incidence and prognosis of lung malignancies was studied in patients who were examined yearly by chest radiography. In 69 patients (12.4%) a lung malignancy was diagnosed, with 28 having a histologically confirmed second primary malignancy. All of these 69 patients were men. The incidence of radiologically detected lung malignancies, both second primary and metastatic cancer, is higher and more prolonged following supraglottic carcinoma than following glottic carcinoma. In 47 patients (68%) without symptoms, the lung malignancy was detected by routine annual chest radiography. The survival rate in patients with lung cancer detected by the yearly radiography was significantly higher than in patients diagnosed after symptoms (median survival 10 and 4 months, respectively). However, taking into account the lead time between early radiologic diagnosis and the time a tumor would have been diagnosed following symptoms, the observed survival benefit of yearly radiography was much lower, or even nil.
在一项对556例喉癌患者（505例男性，51例女性）的回顾性研究中，对每年接受胸部X线检查的患者的肺部恶性肿瘤发病率及预后进行了研究。69例患者（12.4%）被诊断患有肺部恶性肿瘤，其中28例经组织学证实为第二原发性恶性肿瘤。所有这69例患者均为男性。声门上癌患者经放射学检测出的肺部恶性肿瘤（包括第二原发性和转移性癌）的发病率更高，持续时间更长，高于声门癌患者。在47例（68%）无症状患者中，肺部恶性肿瘤通过每年常规胸部X线检查被发现。通过每年X线检查发现肺癌的患者的生存率显著高于出现症状后诊断出的患者（中位生存期分别为10个月和4个月）。然而，考虑到早期放射学诊断与出现症状后肿瘤被诊断之间的时间间隔，每年进行X线检查所观察到的生存获益要低得多，甚至为零。
