Gluckman J L, Crissman J D, Donegan J O
Head Neck Surg. 1980 Nov-Dec;3(2):90-6. doi: 10.1002/hed.2890030203.
In an attempt to define the true frequency of multiple primary squamous-cell carcinomas of the upper aerodigestive tract, 3 separate population groups were studied. The results of this investigation confirmed the high incidence of multicentric carcinomas in the upper aerodigestive tract, lung, and esophagus. The clinical significance of this phenomenon is discussed, particularly its effect on patient survival and its possible relationship to local tumor recurrence. The value of routine panendoscopy in the initial assessment is stressed as well as the need for a lifelong follow-up of these patients.
为了确定上呼吸道消化道原发性多发性鳞状细胞癌的真实发病率，对3个不同人群组进行了研究。这项调查结果证实了上呼吸道消化道、肺和食管多中心癌的高发病率。讨论了这一现象的临床意义，特别是其对患者生存的影响以及与局部肿瘤复发的可能关系。强调了常规全内镜检查在初始评估中的价值以及对这些患者进行终身随访的必要性。
