Worman C P, Burns G F, Barker C R
Clin Exp Immunol. 1978 Mar;31(3):391-6.
It has been demonstrated that in two patients with T-cell Sézary syndrome the pathological cells express a receptor for EA(IgM) when cultured in a medium with foetal calf or autologous serum. A study of the time-course of this rosette formation revealed that a large proportion, but not all, of E-rosetting cells progressively expressed this receptor. In agreement with previous reports by others on the normal T-cell population bearing the IgM receptor, incubation at 37 degrees C in the presence of serum was shown to be a necessary condition. The implications of this pathological subpopulation of T-cells are discussed.
已证实在两名T细胞Sezary综合征患者中，病理细胞在含有胎牛血清或自体血清的培养基中培养时，表达EA（IgM）受体。对这种玫瑰花结形成的时间进程研究表明，大部分（但不是全部）E玫瑰花结形成细胞逐渐表达该受体。与其他人先前关于带有IgM受体的正常T细胞群体的报道一致，在血清存在下于37℃孵育被证明是必要条件。本文讨论了这种病理性T细胞亚群的意义。
