el-Mofty M M, Sakr S A, Osman S I, Daabees A Y, Toulan B A
Zoology Dept., Faculty of Science, Alexandria University, Egypt.
Funct Dev Morphol. 1992;2(3):151-5.
The effect of the anticancer drug adriamycin on the morphology of the erythrocytes as well as some blood parameters were studied in the Egyptian toad Bufo regularis. Injecting the toads subcutaneously in the dorsal lymph sac with adriamycin at a dose level of 2 mg/kg body weight once every three weeks for 12 weeks induced the formation of abnormalities in the cytoplasm and nuclei of the erythrocytes. Its administration also caused severe anaemia, since the number of red blood corpuscles, haemoglobin content and haematocrit values were obviously decreased throughout the whole experimental period. The total leucocytic count was also diminished. On the other hand, the erythrocyte sedimentation rate was increased all over the experiment.
在埃及蟾蜍（Bufo regularis）中研究了抗癌药物阿霉素对红细胞形态以及一些血液参数的影响。以2mg/kg体重的剂量水平，每三周一次，给蟾蜍背部淋巴囊皮下注射阿霉素，持续12周，诱导红细胞的细胞质和细胞核出现异常。其给药还导致严重贫血，因为在整个实验期间，红细胞数量、血红蛋白含量和血细胞比容值均明显降低。白细胞总数也减少。另一方面，在整个实验过程中红细胞沉降率升高。
