Elmofty M, Abdelmeguid N, Sadek I, Essawy A, Abdelaleem E
Oncol Rep. 1997 May-Jun;4(3):657-60. doi: 10.3892/or.4.3.657.
Injection of Egyptian toads Bufo regularis, with adriamycin subcutaneously in the dorsal lymph sac at a dose level of 0.1 mg/toad, once every 3 weeks for 3 months induced pronounced alterations in the blood cells. These alterations were more or less similar to the criteria reported in human leukaemia. These changes were all comparable to those observed after the treatment of the experimental animals with the chemical carcinogen 7,12-dimethylbenz(a)anthracene. It is speculated that toads (Bufo regularis) can be used as biological test animals for screening chemicals or drugs which induce leukaemia in man.
以0.1毫克/蟾蜍的剂量水平，每3周一次，在埃及蟾蜍（Bufo regularis）的背部淋巴囊皮下注射阿霉素，持续3个月，可导致血细胞发生明显变化。这些变化或多或少与人类白血病中报道的标准相似。所有这些变化都与用化学致癌物7,12-二甲基苯并(a)蒽处理实验动物后观察到的变化相当。据推测，蟾蜍（Bufo regularis）可作为生物试验动物，用于筛选可诱发人类白血病的化学物质或药物。
