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Clonal chromosome rearrangements in a uterine myoma.

作者信息

Gibas Z, Griffin C A, Emanuel B S

机构信息

Department of Pathology, Medical College of Pennsylvania, Philadelphia 19129.

出版信息

Cancer Genet Cytogenet. 1988 May;32(1):19-24. doi: 10.1016/0165-4608(88)90306-8.

DOI:10.1016/0165-4608(88)90306-8
PMID:3355997
Abstract

A cytogenetic study of a myoma of uterus with extensive hyaline, myxoid, and cystic degeneration revealed a clonal karyotype with a complex structural rearrangement involving chromosomes #3, #12, #14, #17, and #22. The modal chromosome number of the tumor was 45 due to monosomy #22. Analysis of seven additional myomas of the uterus including five tumors with typical histology and two with degenerative changes showed no clonal abnormalities. Single metaphases with a trisomy and a translocation were detected in two tumors. We conclude that although many uterine myomas appear to have normal karyotypes, clonal chromosome abnormalities are present in some of these tumors.

摘要

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Analysis of molecular cytogenetic alterations in uterine leiomyosarcoma by array-based comparative genomic hybridization.基于阵列比较基因组杂交技术分析子宫平滑肌肉瘤的分子细胞遗传学改变。
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2
In situ hybridization localizes the human putative oncogene GLI to chromosome subbands 12q13.3-14.1.原位杂交将人类假定癌基因GLI定位于染色体亚带12q13.3 - 14.1。
Hum Genet. 1989 Apr;82(1):1-2. doi: 10.1007/BF00288260.
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Giant-cell tumor of bone, stage II, displaying translocation t(12;19)(q13;q13).
骨巨细胞瘤，II期，显示t(12;19)(q13;q13)易位。
Virchows Arch A Pathol Anat Histopathol. 1989;415(4):377-82. doi: 10.1007/BF00718640.
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Characteristic chromosome abnormalities, including rearrangements of 6p, del(7q), +12, and t(12;14), in 44 uterine leiomyomas.44例子宫平滑肌瘤中存在特征性染色体异常，包括6p重排、7q缺失、+12和t(12;14) 。
Hum Genet. 1990 Oct;85(6):605-11. doi: 10.1007/BF00193583.