Gorskaia Iu F, Fridenshteĭn A Ia, Zorina A I
Gematol Transfuziol. 1992 Sep-Oct;37(9-10):3-5.
Guinea pig and rabbit bone marrow and splenic cells with increasing cellular density suppress in vitro formation of fibroblast colonies by rabbit bone marrow clonogenic stromal cells. At the same time guinea pig bone marrow and splenic cells produce a stimulating effect on guinea pig bone marrow CFUf, but they are inhibited by rabbit splenocytes, although to a lesser extent than rabbit bone marrow CFUf. Rabbit blood platelets stimulate the growth of bone marrow CFUf of these animals. However, introduction into the culture of rabbit bone marrow cells combined with platelets eliminates the latter's growth-stimulating effect on stromal clonogenic cells of rabbit bone marrow. The results obtained have evidenced that guinea pig and rabbit bone marrow and lymphoid cell populations contain cells both stimulating and inhibiting CFUf proliferation, and that CFUf of varying animal species have different sensitivity to growth-stimulating and growth-inhibiting effects.
豚鼠和兔子的骨髓及脾细胞，随着细胞密度的增加，会抑制兔子骨髓克隆形成基质细胞在体外形成成纤维细胞集落。与此同时，豚鼠骨髓和脾细胞对豚鼠骨髓CFUf产生刺激作用，但它们会受到兔子脾细胞的抑制，尽管抑制程度比兔子骨髓CFUf要小。兔子血小板会刺激这些动物的骨髓CFUf生长。然而，将兔子骨髓细胞与血小板一起引入培养体系，会消除血小板对兔子骨髓基质克隆细胞的生长刺激作用。所得结果证明，豚鼠和兔子的骨髓及淋巴细胞群体中既含有刺激CFUf增殖的细胞，也含有抑制CFUf增殖的细胞，而且不同动物物种的CFUf对生长刺激和生长抑制作用具有不同的敏感性。
