Matthysse S, Levy D L, Kinney D, Deutsch C, Lajonchere C, Yurgelun-Todd D, Woods B, Holzman P S
Mailman Research Center, McLean Hospital, Belmont, MA 02178.
J Psychiatr Res. 1992 Oct;26(4):461-73. doi: 10.1016/0022-3956(92)90046-q.
An initial course in disentangling complex causal interactions in psychiatric illnesses, we suggest, is finding co-familial traits with classical Mendelian segregation. Starting with non-Mendelian traits, three methods can be used to find underlying Mendelian phenotypes. (1) Statistically-inferred latent traits, with more nearly Mendelian transmission than the measures from which they are derived, can serve as pointers to concrete Mendelian phenotypes. (2) Linkage of non-Mendelian traits to genetic markers, if it can be established, can be followed by searching for phenotypes that discriminate carriers from non-carriers of the imputed trait gene. (3) In the long run, the most successful method is likely to be direct refinement of non-Mendelian behavioral and physiological traits into more fundamental components.
我们认为，解开精神疾病复杂因果相互作用的初步过程是寻找具有经典孟德尔分离特征的共同家族性状。从非孟德尔性状入手，可以使用三种方法来寻找潜在的孟德尔表型。（1）统计推断的潜在性状，其孟德尔传递比从中推导出来的测量值更接近，可以作为具体孟德尔表型的指示。（2）如果能够确定非孟德尔性状与遗传标记的连锁关系，那么接下来可以寻找能够区分推定性状基因携带者和非携带者的表型。（3）从长远来看，最成功的方法可能是将非孟德尔行为和生理性状直接细化为更基本的组成部分。
