Dohi K, Iwano M, Horii Y
1st Dept of Internal Medicine, Nara Medical University.
Nihon Rinsho. 1992 Dec;50(12):2916-20.
Interleukin 6 (IL-6) is a polypeptide mediator regulating immune response, acute phase reaction and hematopoiesis. Disregulating production of IL-6 was suggested to be involved in a variety of chronic inflammatory diseases. IL-6 is an autocrine growth factor for cultured mesangial cells. IL-6 was localized in the mesangial area of the kidney tissue and intraglomerular expression of mRNA, encoding for IL-6 gene, was observed in patients with mesangial proliferative glomerulonephritis (mes PGN). Furthermore, mesangial proliferation was observed in IL-6 transgenic mice. These results suggest that IL-6 is closely associated with the pathogenesis of mesPGN.
白细胞介素6（IL-6）是一种调节免疫反应、急性期反应和造血功能的多肽介质。有研究表明，IL-6产生失调与多种慢性炎症性疾病有关。IL-6是培养的系膜细胞的自分泌生长因子。在系膜增生性肾小球肾炎（mes PGN）患者的肾组织系膜区检测到IL-6的定位，并且观察到编码IL-6基因的mRNA在肾小球内的表达。此外，在IL-6转基因小鼠中观察到系膜增生。这些结果表明，IL-6与mesPGN的发病机制密切相关。
