Iwano M, Dohi K, Hirata E, Horii Y, Shiiki H, Ishikawa H
First Department of Internal Medicine, Nara Medical University, Japan.
Nephron. 1992;62(1):58-65. doi: 10.1159/000186996.
Interleukin 6 (IL-6) is an autocrine growth factor of cultured mesangial cells (MC) and intraglomerular IL-6 production is suggested to be closely associated with the pathogenesis of human mesangial proliferative glomerulonephritis (mesPGN). In this study, to elucidate the mechanisms regulating the intraglomerular production of IL-6, we examined what kinds of stimuli are significant in the induction of IL-6 synthesis in vitro and in vivo. Incubation of cultured mesangial cells with interleukin 1 (IL-1) or bacterial lipopolysaccharide (LPS) induced significant IL-6 production, and intravenous injection of IL-1 or LPS into normal BALB/c mice induced significant intraglomerular IL-6 mRNA expression. Furthermore, we indicated in this study that IL-6 mRNA expression was augmented in the glomeruli of mice with immune complex-mediated glomerulonephritis.
白细胞介素6（IL-6）是培养的系膜细胞（MC）的自分泌生长因子，肾小球内IL-6的产生被认为与人类系膜增生性肾小球肾炎（mesPGN）的发病机制密切相关。在本研究中，为阐明调节肾小球内IL-6产生的机制，我们研究了在体外和体内何种刺激对IL-6合成的诱导具有重要意义。用白细胞介素1（IL-1）或细菌脂多糖（LPS）孵育培养的系膜细胞可诱导显著的IL-6产生，向正常BALB/c小鼠静脉注射IL-1或LPS可诱导显著的肾小球内IL-6 mRNA表达。此外，我们在本研究中表明，在免疫复合物介导的肾小球肾炎小鼠的肾小球中，IL-6 mRNA表达增加。
