Fairweather D B, Kerr J S, Hindmarch I
Human Psychopharmacology Research Unit, Robens Institute, University of Surrey, Milford Hospital, Godalming, UK.
Eur J Clin Pharmacol. 1992;43(6):597-601. doi: 10.1007/BF02284957.
We gave 24 healthy elderly volunteers with a perceived sleep onset of at least 30 minutes zolpidem 5 mg, zolpidem 10 mg, or placebo for 7 days in a double-blind, three-way, crossover study. The morning after nocturnal dosing, psychomotor performance and cognitive ability were measured using tests which are sensitive to the residual effects of hypnotics and to the effects of drugs on various indicators of sleep quality. The tests were: Choice Reaction Time; Tracking; Critical Flicker Fusion Threshold; Memory Scanning; Word Recognition; the Leeds Sleep Evaluation Questionnaire and Line Analogue Rating Scales. Zolpidem produced a subjective improvement in sleep but did not impair performance the following day. Furthermore, during repeated administration, there was no tolerance to the effects of sleep latency and quality of sleep, nor adverse effects on task performance.
在一项双盲、三臂、交叉研究中，我们让24名自觉入睡时间至少为30分钟的健康老年志愿者服用5毫克唑吡坦、10毫克唑吡坦或安慰剂，为期7天。夜间给药后的早晨，使用对催眠药残留效应以及药物对各种睡眠质量指标的效应敏感的测试来测量精神运动表现和认知能力。这些测试包括：选择反应时间；跟踪；临界闪烁融合阈值；记忆扫描；单词识别；利兹睡眠评估问卷和视觉模拟评分量表。唑吡坦在睡眠方面产生了主观改善，但次日并未损害表现。此外，在重复给药期间，对睡眠潜伏期和睡眠质量的影响没有耐受性，对任务表现也没有不良影响。
