老年人使用唑吡坦所致的认知与平衡功能障碍：一项系统综述

Cognitive and balance dysfunctions due to the use of zolpidem in the elderly: a systematic review.

作者信息

Tavares Guilherme, Kelmann Gizela, Tustumi Francisco, Tundisi Catherine Nardini, Silveira Bárbara Regina Bruço, Barbosa Bruno Maximiliano Augusto Colombo, Winther Diana Bragança, Boutros Eduarda Conte, Villar Gabriel Dos Santos, Brunocilla Giovanna, Lourenção Gustavo Rodrigues Caldas, Ferreira Jiulia Giovanna Aranha, Bernardo Wanderley Marques

机构信息

Department of Evidence-Based Medicine, Centro Universitário Lusíada - Santos, SP, Brazil.

Department of Evidence-Based Medicine, Universidade de São Paulo - São Paulo, SP, Brazil.

出版信息

Dement Neuropsychol. 2021 Jul-Sep;15(3):396-404. doi: 10.1590/1980-57642021dn15-030013.

DOI:10.1590/1980-57642021dn15-030013

PMID:34630929

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC8485645/

Abstract

UNLABELLED

Zolpidem is one of the most widely prescribed hypnotic (non-benzodiazepine) agents for sleep disorder. Recently, an increase in the demand for this drug has been observed, mainly in the elderly population.

OBJECTIVE

This study aims to analyze the acute effect of zolpidem on cognitive and balance dysfunctions in the elderly population.

METHODS

A study was conducted by two independent researchers in four virtual scientific information bases and included randomized controlled trials. The studies evaluated elderly patients using zolpidem. Cognitive and balance dysfunctions were analyzed.

RESULTS

Six articles were included. The mean age of the participants in the studies was 69 years. The following zolpidem dosages were evaluated: 5, 6.25, 10, and 12.5 mg. Comparing zolpidem and placebo, relating to the cognitive dysfunctions, there is no statistically significant difference between the groups. However, in relation to balance dysfunctions, there is a statistically significant difference between the intervention and the comparison, favoring placebo.

CONCLUSIONS

Zolpidem, even in usual doses (5 mg and 10 mg), has shown to increase the risk for balance dysfunctions. However, this does not occur in relation to cognitive changes.

摘要