Hoeldtke R D, Davis K M, Hshieh P B, Gaspar S R, Dworkin G E
Department of Medicine, Temple University Hospital, Philadelphia, Pennsylvania.
Muscle Nerve. 1992 Aug;15(8):926-31. doi: 10.1002/mus.880150810.
There has been recent interest in measuring sympathetic sudomotor function by autonomic surface potential analysis. The purpose of the present study was to assess factors affecting the reproducibility of the test. We determined the within-day and between-day reproducibility in 24 healthy volunteers. We used an increasing rather than a constant electrical stimulus to minimize habituation. The amplitudes were still highly variable (an average within-day coefficient of variation in the soles of 35%). Habituation did not, however, affect the latencies of the responses, which were much more reproducible (an average within-day coefficient of variation in the soles of 8%). Studies of between-day reproducibility revealed that the mean amplitudes were lower on day 2 vs. day 1 (0.706 +/- 0.10 vs. 0.85 +/- 0.10 mV in the soles, P less than 0.01) but the mean latencies were similar on the different testing days (2.09 +/- .04 seconds for the soles on day 1 vs. 2.16 +/- .05 seconds on day 2). We also assessed the sensitivity of surface potential analysis and report the results of testing 35 patients with far advanced autonomic neuropathy.
最近，人们对通过自主神经表面电位分析来测量交感神经汗腺功能产生了兴趣。本研究的目的是评估影响该测试可重复性的因素。我们在24名健康志愿者中测定了日内和日间的可重复性。我们使用逐渐增加而非恒定的电刺激来尽量减少适应性。然而，振幅仍然高度可变（脚底日内变异系数平均为35%）。不过，适应性并未影响反应潜伏期，潜伏期的可重复性要高得多（脚底日内变异系数平均为8%）。日间可重复性研究表明，第2天的平均振幅低于第1天（脚底分别为0.706±0.10与0.85±0.10 mV，P<0.01），但不同测试日的平均潜伏期相似（第1天脚底为2.09±.04秒，第2天为2.16±.05秒）。我们还评估了表面电位分析的敏感性，并报告了对35例晚期自主神经病变患者的测试结果。
