Carter Wendy W, Gompf Sandra G, Toney John F, Greene John N, Cutolo Edward P
University of South Florida, Tampa, Florida, USA.
AIDS Read. 2004 Jan;14(1):41-9.
Acanthamoeba, a free-living ameba, has been reported to infect humans with subacute encephalitis, sinusitis, or keratitis. Multiple cases of Acanthamoeba sinusitis with dissemination have been reported in association with AIDS, with high mortality. We report successful treatment of a 35-year-old woman who presented with sinusitis that progressed to disseminated acanthamebiasis as her initial manifestation of AIDS. To our knowledge, our patient was one of the few and longest-lived survivors of disseminated Acanthamoeba infection with AIDS. As with other opportunistic infections, early aggressive therapy including HAART may alter the outcome in this almost uniformly fatal disease.
棘阿米巴是一种自由生活的阿米巴原虫，据报道可感染人类引发亚急性脑炎、鼻窦炎或角膜炎。已有多例播散性棘阿米巴鼻窦炎与艾滋病相关的病例报道，死亡率很高。我们报告了一例35岁女性患者的成功治疗案例，该患者最初表现为鼻窦炎，随后进展为播散性棘阿米巴病，这是她艾滋病的首发表现。据我们所知，我们的患者是播散性棘阿米巴感染合并艾滋病的少数长期存活者之一。与其他机会性感染一样，早期积极治疗，包括高效抗逆转录病毒治疗（HAART），可能会改变这种几乎一致致命疾病的预后。
