Department of Pharmacy, University of Texas Southwestern Medical Center, Dallas, Texas, USA.
Department of Internal Medicine, University of Texas Southwestern Medical Center, Dallas, Texas, USA.
Antimicrob Agents Chemother. 2019 Dec 20;64(1). doi: 10.1128/AAC.01127-19.
Miltefosine is an alkylphosphocholine compound that is used primarily for treatment of leishmaniasis and demonstrates and antiamebic activity against species. Recommendations for treatment of amebic encephalitis generally include miltefosine therapy. Data indicate that treatment with an amebicidal concentration of at least 16 μg/ml of miltefosine is required for most species. Although there is a high level of mortality associated with amebic encephalitis, a paucity of data regarding miltefosine levels in plasma and cerebrospinal fluid exists in the literature. We found that despite aggressive dosing (oral miltefosine 50 mg every 6 h) and therapeutic plasma levels, the miltefosine concentration in cerebrospinal fluid was negligible in a patient with AIDS and encephalitis.
米替福新是一种烷基磷胆碱化合物，主要用于治疗利什曼病，并对 种阿米巴原虫具有 和 抗阿米巴活性。治疗阿米巴脑炎的建议通常包括米替福新治疗。数据表明，治疗大多数 种阿米巴原虫需要米替福新的杀阿米巴浓度至少为 16μg/ml。尽管阿米巴脑炎的死亡率很高，但文献中关于米替福新在血浆和脑脊液中的水平的数据很少。我们发现，尽管进行了积极的给药（口服米替福新 50mg，每 6 小时一次）和治疗性血浆水平，艾滋病毒感染者和脑炎患者的脑脊液中米替福新浓度可忽略不计。
