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本文引用的文献

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Phosphorylation of extracellular signal-regulated kinase in primary afferent neurons by noxious stimuli and its involvement in peripheral sensitization.伤害性刺激对初级传入神经元中细胞外信号调节激酶的磷酸化作用及其在外周敏化中的作用。
J Neurosci. 2002 Sep 1;22(17):7737-45. doi: 10.1523/JNEUROSCI.22-17-07737.2002.
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Acute sensitization by NGF of the response of small-diameter sensory neurons to capsaicin.神经生长因子对小直径感觉神经元对辣椒素反应的急性致敏作用。
J Neurophysiol. 2001 Dec;86(6):2931-8. doi: 10.1152/jn.2001.86.6.2931.
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Nociceptor sensitization by extracellular signal-regulated kinases.细胞外信号调节激酶介导的伤害感受器敏化。
J Neurosci. 2001 Sep 1;21(17):6933-9. doi: 10.1523/JNEUROSCI.21-17-06933.2001.
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Protein kinase C activation potentiates gating of the vanilloid receptor VR1 by capsaicin, protons, heat and anandamide.蛋白激酶C激活增强了辣椒素、质子、热和花生四烯酸乙醇胺对香草酸受体VR1的门控作用。
J Physiol. 2001 Aug 1;534(Pt 3):813-25. doi: 10.1111/j.1469-7793.2001.00813.x.
5
Chemokines and glycoprotein120 produce pain hypersensitivity by directly exciting primary nociceptive neurons.趋化因子和糖蛋白120通过直接刺激初级伤害性神经元产生痛觉过敏。
J Neurosci. 2001 Jul 15;21(14):5027-35. doi: 10.1523/JNEUROSCI.21-14-05027.2001.
6
Bradykinin and nerve growth factor release the capsaicin receptor from PtdIns(4,5)P2-mediated inhibition.缓激肽和神经生长因子使辣椒素受体从磷脂酰肌醇（4,5）二磷酸介导的抑制作用中释放出来。
Nature. 2001 Jun 21;411(6840):957-62. doi: 10.1038/35082088.
7
Potentiation of capsaicin receptor activity by metabotropic ATP receptors as a possible mechanism for ATP-evoked pain and hyperalgesia.代谢型ATP受体对辣椒素受体活性的增强作用：ATP诱发疼痛和痛觉过敏的一种可能机制
Proc Natl Acad Sci U S A. 2001 Jun 5;98(12):6951-6. doi: 10.1073/pnas.111025298. Epub 2001 May 22.
8
Sustained sensitization and recruitment of rat cutaneous nociceptors by bradykinin and a novel theory of its excitatory action.缓激肽对大鼠皮肤伤害感受器的持续致敏和募集作用及其兴奋作用的新理论
J Physiol. 2001 Apr 1;532(Pt 1):229-39. doi: 10.1111/j.1469-7793.2001.0229g.x.
9
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Nat Rev Neurosci. 2001 Jan;2(1):24-32. doi: 10.1038/35049004.
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ATP as a peripheral mediator of pain.三磷酸腺苷作为疼痛的外周介质。
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胃肠道传入神经的致敏作用。

Sensitisation of gastrointestinal tract afferents.

作者信息

McMahon S B

机构信息

Centre for Neuroscience Research, Kings College London, London Bridge, UK.

出版信息

Gut. 2004 Mar;53 Suppl 2(Suppl 2):ii13-5. doi: 10.1136/gut.2003.033431.

DOI:10.1136/gut.2003.033431
PMID:14960552
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1867771/
Abstract

Sensory innervation of the viscera serves a number of important functions, including regulation of visceral motility and secretory activity, and transmission of visceral sensations, including pain. There are many ways in which the sensitivity of visceral sensory neurones might be modulated, and these are discussed. Altered sensory neurone responsiveness may contribute to pathophysiological states such as irritable bowel syndrome, and the mechanisms leading to sensory neurone sensitisation offer novel targets for the treatment of such disorders.

摘要

内脏的感觉神经支配具有许多重要功能，包括调节内脏运动和分泌活动，以及传递包括疼痛在内的内脏感觉。内脏感觉神经元的敏感性可能通过多种方式进行调节，本文将对此进行讨论。感觉神经元反应性的改变可能导致诸如肠易激综合征等病理生理状态，而导致感觉神经元致敏的机制为治疗此类疾病提供了新的靶点。