一种植物双生病毒（印度绿豆黄花叶病毒）的DNA-A组分在出芽酵母细胞中复制。
The DNA-A component of a plant geminivirus (Indian mung bean yellow mosaic virus) replicates in budding yeast cells.
作者信息
Raghavan Vineetha, Malik Punjab S, Choudhury Nirupam Roy, Mukherjee Sunil K
机构信息
Plant Molecular Biology, International Center for Genetic Engineering and Biotechnology, Aruna Asaf Ali Marg, New Delhi 110067, India.
出版信息
J Virol. 2004 Mar;78(5):2405-13. doi: 10.1128/jvi.78.5.2405-2413.2004.
Abstract
Understanding the biochemistry of DNA replication of the plant DNA viruses is important for the development of antiviral strategies. Since DNA replication is little studied in plants, a genetically tractable, easily culturable, eukaryotic model system is required to pursue such studies in a facile manner. Here we report the development of a yeast model system that supports DNA replication of a chosen geminivirus strain, Indian mung bean yellow mosaic virus. The replication of plasmid DNA in the model system relies specifically on the virus-derived elements and factors. Usage of this model system revealed the role of at least one hitherto unknown viral factor for viral DNA replication. The episomal characteristic of single-strandedness of replicated plasmid DNA was shown, and the expression of viral genes was also confirmed. This model system is expected to shed light on the machinery and mechanism involved in geminiviral DNA replication in plants.
摘要
了解植物DNA病毒的DNA复制生物化学对于抗病毒策略的开发至关重要。由于植物中的DNA复制研究较少，因此需要一个遗传上易于操作、易于培养的真核模型系统来方便地进行此类研究。在此，我们报告了一种酵母模型系统的开发，该系统支持所选双生病毒株——印度绿豆黄花叶病毒的DNA复制。模型系统中质粒DNA的复制特别依赖于病毒衍生的元件和因子。使用该模型系统揭示了至少一种迄今未知的病毒因子在病毒DNA复制中的作用。已证明复制的质粒DNA单链的附加体特征，并且也证实了病毒基因的表达。该模型系统有望阐明植物中双生病毒DNA复制所涉及的机制和原理。
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本文引用的文献
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Multitasking in replication is common among geminiviruses.双生病毒中复制过程中的多任务处理很常见。
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High-affinity Rep-binding is not required for the replication of a geminivirus DNA and its satellite.双生病毒DNA及其卫星分子的复制不需要高亲和力的Rep结合。
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