Molecular Virology Laboratory, School of Life Sciences, Jawaharlal Nehru University, New Delhi, India.
Arch Virol. 2022 Feb;167(2):307-326. doi: 10.1007/s00705-021-05338-x. Epub 2022 Jan 26.
Geminiviruses are a major threat to agriculture in tropical and subtropical regions of the world. Geminiviruses have small genome with limited coding capacity. Despite this limitation, these viruses have mastered hijacking the host cellular metabolism for their survival. To compensate for the small size of their genome, geminiviruses encode multifunctional proteins. In addition, geminiviruses associate themselves with satellite DNA molecules which also encode proteins that support the virus in establishing successful infection. Geminiviral proteins recruit multiple host factors, suppress the host defense, and manipulate host metabolism to establish infection. We have updated the knowledge accumulated about the proteins of geminiviruses and their satellites in the context of pathogenesis in a single review. We also discuss their interactions with host factors to provide a mechanistic understanding of the infection process.
双生病毒是世界热带和亚热带地区农业的主要威胁。双生病毒的基因组较小，编码能力有限。尽管存在这种限制，但这些病毒已经掌握了劫持宿主细胞代谢来维持自身生存的能力。为了弥补基因组的小尺寸，双生病毒编码多功能蛋白。此外，双生病毒与卫星 DNA 分子结合，卫星 DNA 分子也编码支持病毒成功感染的蛋白质。双生病毒蛋白招募多种宿主因子，抑制宿主防御，并操纵宿主代谢以建立感染。我们在一篇综述中更新了关于双生病毒及其卫星在发病机制方面积累的知识。我们还讨论了它们与宿主因子的相互作用，以提供对感染过程的机制理解。
