Wu Shu-Fen, Chen Walter
Department of Pediatric, China Medical University Hospital, No. 2, Yuh Der Road, Taichung, Taiwan.
Acta Paediatr Taiwan. 2003 Sep-Oct;44(5):297-9.
We report an outbreak of scombroid poisoning at one kindergarten on September 25, 1997. There were 94 cases. The onset of symptoms of scombrotoxin after ingestion of fish is rapid (40 to 50 minutes after consumption). Clinical manifestation consisted of hyperemia, particularly on the face and neck (94.7%), nausea and vomiting (17.0%), abdominal pain (17.0%), pruritus (4.3%), headache and dizziness (4.3%) and diarrhea (3.2%). The duration of symptoms was 3 hours on average. Most patients responded to antihistamine very well. The poisoning was caused by the ingestion of spoiled scombroid fish. The tissues of scombroid fish had undergone a number of changes provoked by bacteria and the uncooked fish containing 2,104 ppm of histamine whereas cooked fish containing 1,980 ppm (198 mg/100 gm) of histamine was found in this accident.
我们报告了1997年9月25日在一所幼儿园发生的一次组胺中毒事件。共有94例病例。摄入鱼类后组胺中毒症状的发作迅速（食用后40至50分钟）。临床表现包括充血，尤其是面部和颈部（94.7%）、恶心和呕吐（17.0%）、腹痛（17.0%）、瘙痒（4.3%）、头痛和头晕（4.3%）以及腹泻（3.2%）。症状持续时间平均为3小时。大多数患者对抗组胺药反应良好。此次中毒是由于食用了变质的鲭科鱼类所致。在此次事件中发现，鲭科鱼类的组织因细菌作用发生了一些变化，生鱼中组胺含量为2104 ppm，而熟鱼中组胺含量为1980 ppm（198毫克/100克）。
