Mattarozzi Katia, Stracciari Andrea, Vignatelli Luca, D'Alessandro Roberto, Morelli Maria Cristina, Guarino Maria
Department of Psychology, University of Bologna, Italy.
Arch Neurol. 2004 Feb;61(2):242-7. doi: 10.1001/archneur.61.2.242.
The long-term effects of liver transplantation (LT) on minimal hepatic encephalopathy are poorly documented.
To assess the cognitive performance of patients with cirrhosis and without overt encephalopathy, before and after LT.
Longitudinal study comparing cognitive performance of patients with cirrhosis before LT and 6 to 18 months after LT, with matched control patients.
University medical center.
Six months after LT, patients had improved their performance in visuospatial and selective attention, visuospatial short-term and long-term memory, and language tasks. After 18 months, a further improvement was found for selective attention and verbal short-term memory, while no other cognitive functions varied over time.
The present findings confirm preliminary studies showing that LT improves cognitive functions in patients with cirrhosis. The cognitive improvement is not generalized, but appears prominent in attention and memory and, once achieved, remains stable. Rates of recovery differ, being early for some functions and later for others.
肝移植（LT）对轻微肝性脑病的长期影响记录不足。
评估肝硬化且无明显脑病患者在肝移植前后的认知表现。
纵向研究，比较肝移植前及肝移植后6至18个月肝硬化患者与匹配的对照患者的认知表现。
大学医学中心。
肝移植后6个月，患者在视觉空间和选择性注意力、视觉空间短期和长期记忆以及语言任务方面的表现有所改善。18个月后，选择性注意力和言语短期记忆进一步改善，而其他认知功能未随时间变化。
目前的研究结果证实了初步研究，表明肝移植可改善肝硬化患者的认知功能。认知改善并非普遍存在，而是在注意力和记忆方面较为突出，一旦实现则保持稳定。恢复速度不同，某些功能恢复早，其他功能恢复晚。
