Hitchon C A, el-Gabalawy H S
Department of Medicine, University of Manitoba, Winnipeg, Manitoba, Canada.
Clin Exp Rheumatol. 2003 Sep-Oct;21(5 Suppl 31):S28-36.
Early diagnosis and therapeutic intervention are needed to prevent the morbidity related to erosive arthropathies such as rheumatoid arthritis (RA), yet it is difficult to distinguish various forms of synovitis early in the disease course. The availability of synovial tissue biopsy techniques has facilitated the analysis of synovial tissue from patients with early disease. Comparison of the histopathologic features of synovial tissue in early RA, established RA, and in non-RA synovitis has shown subtle, but potentially important differences in histologic features, cytokine and protease expression patterns, and apoptosis. Ultimately, it remains to be shown definitively that analysis of the histopathological features of synovial tissue early in disease is of independent value in identifying patients destined to have persistent synovitis or erosive disease, and in turn, in allocating patients to specific therapeutic strategies.
需要进行早期诊断和治疗干预，以预防与侵蚀性关节病（如类风湿关节炎（RA））相关的发病率，但在疾病早期很难区分各种形式的滑膜炎。滑膜组织活检技术的应用有助于对早期疾病患者的滑膜组织进行分析。对早期类风湿关节炎、确诊类风湿关节炎和非类风湿性滑膜炎患者滑膜组织的组织病理学特征进行比较，结果显示在组织学特征、细胞因子和蛋白酶表达模式以及细胞凋亡方面存在细微但可能重要的差异。最终，仍有待明确证明，对疾病早期滑膜组织的组织病理学特征进行分析，对于识别注定会出现持续性滑膜炎或侵蚀性疾病的患者，以及进而为患者分配特定的治疗策略具有独立价值。
